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1045861-30-0

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1045861-30-0 Usage

General Description

2-Amino-4-(trifluoromethyl)pyrimidin-5-ylboronic acid is a chemical compound with the formula C6H6BF3N3O2. It is a boronic acid derivative containing a pyrimidine ring with a trifluoromethyl group and an amino group attached to it. 2-aMino-4-(trifluoroMethyl)pyriMidin-5-ylboronic acid is commonly used in organic synthesis as a reagent for Suzuki-Miyaura cross-coupling reactions, which is a versatile method for forming carbon-carbon bonds. It has also been reported to have potential applications in medicinal chemistry and drug development due to its ability to modify and functionalize organic molecules. The presence of the boronic acid group makes it a valuable tool in the development of new pharmaceuticals and biologically active compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 1045861-30-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,5,8,6 and 1 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1045861-30:
(9*1)+(8*0)+(7*4)+(6*5)+(5*8)+(4*6)+(3*1)+(2*3)+(1*0)=140
140 % 10 = 0
So 1045861-30-0 is a valid CAS Registry Number.

1045861-30-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name [2-amino-4-(trifluoromethyl)pyrimidin-5-yl]boronic acid

1.2 Other means of identification

Product number -
Other names (2-Amino-4-(trifluoromethyl)pyrimidin-5-yl)boronic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1045861-30-0 SDS

1045861-30-0Downstream Products

1045861-30-0Relevant articles and documents

Identification of NVP-BKM120 as a potent, selective, orally bioavailable class i PI3 kinase inhibitor for treating cancer

Burger, Matthew T.,Pecchi, Sabina,Wagman, Allan,Ni, Zhi-Jie,Knapp, Mark,Hendrickson, Thomas,Atallah, Gordana,Pfister, Keith,Zhang, Yanchen,Bartulis, Sarah,Frazier, Kelly,Ng, Simon,Smith, Aaron,Verhagen, Joelle,Haznedar, Joshua,Huh, Kay,Iwanowicz, Ed,Xin, Xiaohua,Menezes, Daniel,Merritt, Hanne,Lee, Isabelle,Wiesmann, Marion,Kaufman, Susan,Crawford, Kenneth,Chin, Michael,Bussiere, Dirksen,Shoemaker, Kevin,Zaror, Isabel,Maira, Sauveur-Michel,Voliva, Charles F.

, p. 774 - 779 (2011/12/03)

Phosphoinositide-3-kinases (PI3Ks) are important oncology targets due to the deregulation of this signaling pathway in a wide variety of human cancers. Herein we describe the structure guided optimization of a series of 2-morpholino, 4-substituted, 6-heterocyclic pyrimidines where the pharmacokinetic properties were improved by modulating the electronics of the 6-position heterocycle, and the overall druglike properties were fine-tuned further by modification of the 4-position substituent. The resulting 2,4-bismorpholino 6-heterocyclic pyrimidines are potent class I PI3K inhibitors showing mechanism modulation in PI3K dependent cell lines and in vivo efficacy in tumor xenograft models with PI3K pathway deregulation (A2780 ovarian and U87MG glioma). These efforts culminated in the discovery of 15 (NVP-BKM120), currently in Phase II clinical trials for the treatment of cancer.

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