1045863-63-5Relevant academic research and scientific papers
Mukaiyama reagent-promoted metal-free preparation of alkynyl sulfones and phosphonates under mild conditions
Qi, Danyang,Dong, Wanrong,Peng, Zhihong,Zhang, Yingjun,An
, (2019)
An efficient and mild route for the formation sulfur or phosphor-substituted alkynes was herein demonstrated. The Mukaiyama reagent-mediated transformation started from easily-accessible substrates without carbon-carbon triple bonds, and the reaction proceeded under mild conditions (room temperature) in a one-pot manner, requiring for no transition metal-catalysts. The practical protocol featured for good functional groups tolerance (up to 41 examples) and high efficiency (up to 91% yields) towards alkynyl sulfones and alkynyl phosphonates at low cost.
Base-induced one-pot preparation of N- or P-substituted alkynes
Zhang, Yang,Zhang, Yanqin,Xiao, Jing,Peng, Zhihong,Dong, Wanrong,An, Delie
supporting information, p. 7806 - 7815 (2015/12/31)
An efficient method for the formation of C(sp)-N or C(sp)-P bonds is described. The facile transformation proceeds under mild conditions (0 or -20 °C) in a one-pot manner, and does not require transition-metal catalysts. The base-induced protocol exhibits good functional group tolerance (up to 44 examples) and high efficiency (up to 94 % yield) towards rare heteroatom-substituted acetylenes (N or P). Furthermore, the proposed mechanism was supported by the isolation of a key intermediate. An efficient method for the formation of C(sp)-N or C(sp)-P bonds is described. The facile transformation proceeds in the absence of any transition-metal catalysts under mild conditions (0 or -20 °C) in a one-pot manner with good functional group compatibility and with high efficiency.
An efficient preparation of β-aryl-β-ketophosphonates by the TFAA/H3PO4-mediated acylation of arenes with phosphonoacetic acids
Luke, George P.,Seekamp, Christopher K.,Wang, Zhe-Qing,Chenard, Bertrand L.
, p. 6397 - 6400 (2008/12/21)
(Chemical Equation Presented) β-Aryl-β-ketophosphonates can be efficiently prepared in good yield by using a TFAA/85% H3PO 4-mediated acylation of electron-rich arenes with phosphonoacetic acids. The conditions offer advantages over
METHODS FOR PREPARING ARYL-SUBSTITUTED KETOPHOSPHONATES
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Page/Page column 18, (2008/12/08)
Methods are provided for the synthesis of aryl-substituted ketophosphonates of the Formula (I): wherein variables are as described herein. Such compounds are useful as reagents for olefination reactions, and as intermediates in the synthesis of certain biologically active agents.
