1045863-67-9Relevant academic research and scientific papers
METHODS FOR PREPARING ARYL-SUBSTITUTED KETOPHOSPHONATES
-
Page/Page column 21-22, (2008/12/08)
Methods are provided for the synthesis of aryl-substituted ketophosphonates of the Formula (I): wherein variables are as described herein. Such compounds are useful as reagents for olefination reactions, and as intermediates in the synthesis of certain biologically active agents.
An efficient preparation of β-aryl-β-ketophosphonates by the TFAA/H3PO4-mediated acylation of arenes with phosphonoacetic acids
Luke, George P.,Seekamp, Christopher K.,Wang, Zhe-Qing,Chenard, Bertrand L.
, p. 6397 - 6400 (2008/12/21)
(Chemical Equation Presented) β-Aryl-β-ketophosphonates can be efficiently prepared in good yield by using a TFAA/85% H3PO 4-mediated acylation of electron-rich arenes with phosphonoacetic acids. The conditions offer advantages over
