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104594-70-9

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99% Caffeic Acid Phenethyl Ester Powder CAPE
Cas No: 104594-70-9
USD $ 380.0-465.0 / Kilogram 1 Kilogram 10 Metric Ton/Week Shaanxi Yuantai Biological Technology Co., Ltd. Contact Supplier
Caffeic Acid Phenethyl Easter CAPE
Cas No: 104594-70-9
No Data 10 Gram 500 Kilogram/Month kern enterprises Contact Supplier
Phenethyl caffeate
Cas No: 104594-70-9
No Data No Data No Data Shanghai Yanchu chemicals Co., Ltd Contact Supplier
Phenethyl caffeate Manufacturer/High quality/Best price/In stock
Cas No: 104594-70-9
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
99% up USP standard Caffeic Acid Phenethyl Ester / Phenethyl Caffeate / CAPE Powder
Cas No: 104594-70-9
No Data 25 Kilogram 50 Metric Ton/Month Sinoway Industrial Co., Ltd. Contact Supplier
High quality Phenethyl Caffeate supplier in China
Cas No: 104594-70-9
No Data 1 Metric Ton 30 Metric Ton/Month Simagchem Corporation Contact Supplier
Phenethyl caffeate
Cas No: 104594-70-9
USD $ 5.0-30.0 / Kilogram 1 Kilogram 200 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
Phenethyl caffeate
Cas No: 104594-70-9
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
Phenethyl caffeate
Cas No: 104594-70-9
No Data 25 Kilogram 1500 Metric Ton/Year Hefei TNJ chemical industry co.,ltd Contact Supplier
Factory price Cosmetic PHENETHYL CAFFEATE 104594-70-9 Manufacturer
Cas No: 104594-70-9
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier

104594-70-9 Usage

Description

Phenylethyl caffeate is one of the allergens of propolis (bee glue); also contained in poplar-bud secretions.

Chemical Properties

Off-White Solid

Uses

Phenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.

Uses

antineoplastic, antiinflammatory, immunomodulator, NFkB blocker

Uses

Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.

Biological Activity

Antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF- κ B activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.

Contact allergens

Capee is one of the allergens of propolis (bee glue). It is also contained in poplar bud secretions.

Biochem/physiol Actions

CAPE exhibits several properties such as anticarcinogenic, immunomodulatory activities, antioxidant, antiviral, anti-inflammatory, hypoglycaemic effect, cardioprotective and inhibits gastric secretion. It also has an inhibitory effect on fibroblasts growth factor type 2 (FGF-2), a tumor growth factor in breast cancer.

Anticancer Research

Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) is a natural phenolcompound and an active component of propolis from honeybee hives. Torkiet al. (2017)investigated the effect of phosphatidylinositol 3-kinase/AKT/mammaliantarget of rapamycin (PI3K/Akt/mTOR) signaling pathway dual inhibitor, NVP-BEZ235,and CAPE on TNBC cell line (MDA-MB-231), stimulated withtransforming growth factor (TGF)-β1 for 14 days. CAPE in combination with NVP-BEZ235synergistically inhibited cell growth and reduced CXCR4 expression.Also, treatment of MDA-MB-231 cells with CAPE and NVP-BEZ235 time-dependentlyinhibited the expression of p-Forkhead Box O3a (FOXO3a). In a nutshell,these results indicate that tumour metastasis and progression in TNBC cellscan be effectively reduced through the concurrent use of NVP-BEZ235 and CAPE(Torki et al. 2017).

References

1) Sudine et al. (1993) Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett. 21 329 2) Natarajan et al. (1996) Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc. Natl. Acad. Sci. USA 93 9090 3) Chiao et al. (1995). Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells; Cancer Res. 55 3576 4) Orban et.al. (2000), Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation; Neuroimmunomodulation, 7 99
InChI:InChI=1/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+

104594-70-9 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (P2088)  Phenethyl Caffeate  >98.0%(HPLC) 104594-70-9 25mg 260.00CNY Detail
TCI America (P2088)  Phenethyl Caffeate  >98.0%(HPLC) 104594-70-9 250mg 1,400.00CNY Detail
Sigma (C8221)  Caffeic acid phenethyl ester  ≥97% (HPLC), powder 104594-70-9 C8221-1G 5,309.46CNY Detail

104594-70-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name phenethyl caffeate

1.2 Other means of identification

Product number -
Other names Phenethyl 3-(3,4-dihydroxyphenyl)acrylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:104594-70-9 SDS

104594-70-9Related news

Phenethyl caffeate (cas 104594-70-9) benzo[kl]xanthene lignan with DNA interacting properties induces DNA damage and apoptosis in colon cancer cells08/17/2019

AimsPhenethyl caffeate benzoxanthene lignan (PCBL) is a synthetic compound with DNA interacting, antiangiogenic, antiproliferative and tumor cell death inducing abilities. Though PCBL exhibits the qualities of a prospective antitumor agent, the basic mechanism of PCBL induced cell death remains ...detailed

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