1046119-63-4

Basic information

• Product Name: N-[Methyl[1-[6-(trifluoroMethyl)-3-pyridinyl]ethyl]-λ4-sulfanylidene]cyanaMide
• Synonyms: N-[Methyl[1-[6-(trifluoroMethyl)-3-pyridinyl]ethyl]-λ4-sulfanylidene]cyanaMide;[1-[6-(Trifluoromethyl)pyridin-3-yl]ethyl](methyl)-lambda4-sulfanylidenecyanamide;[Methyl[1-[6-(trifluoromethyl)-3-pyridyl]ethyl]sulfanylidene]cyanamide;5-(1-Cyanoiminoethyl)-2-(trifluoromethyl)pyridine;[methyl-[1-[6-(trifluoromethyl)pyridin-3-yl]ethyl]-$l^{4}-sulfanylidene]cyanamide
• CAS NO: 1046119-63-4
• Molecular Formula: C₁₀H₁₀F₃N₃S
• Molecular Weight: 261.2667096
• Mol File: 1046119-63-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: N-[Methyl[1-[6-(trifluoroMethyl)-3-pyridinyl]ethyl]-λ4-sulfanylidene]cyanaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[Methyl[1-[6-(trifluoroMethyl)-3-pyridinyl]ethyl]-λ4-sulfanylidene]cyanaMide(1046119-63-4)
• EPA Substance Registry System: N-[Methyl[1-[6-(trifluoroMethyl)-3-pyridinyl]ethyl]-λ4-sulfanylidene]cyanaMide(1046119-63-4)

Safety Data

• Hazardous Substances Data: 1046119-63-4(Hazardous Substances Data)

Usage

Uses

N-[Methyl[1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-λ4-sulfanylidene]cyanamide is an intermediate in the synthesis of Sulfoxaflor (S755005), a new insecticide which acts as an insect neurotoxin, and is the only member of class of chemicals called the sulfoximines which act on the central nervous system of insects with much lower toxicity to mammals.

Upstream product

• 420-04-2 CYANAMID 
• 946578-42-3 5-[1-(methylsulfinyl)ethyl]-2-trifluoromethylpyridine 
• 1045854-57-6 3-(methylthio)-1-(pyrrolidin-1-yl)-1-butene 
• 16630-52-7 3-(methylthio)butyraldehyde 
• 1380070-36-9 1,1,1-trifluoro-6-(methylthio)-5-(pyrrolidine-1-ylmethylene)hept-3-en-2-one 

Downstream Products

• 946578-00-3 sulfoxaflor 

Relevant articles and documents

Anodic Dehydrogenative Cyanamidation of Thioethers: Simple and Sustainable Synthesis of N-Cyanosulfilimines

A novel and very simple to perform electrochemical approach for the synthesis of several N-cyanosulfilimines in good to excellent yields was established. This method provides access to biologically relevant sulfoximines by consecutive oxidation using electro-generated periodate. This route can be easily scaled-up to gram quantities. The S,N coupling is carried out at an inexpensive carbon anode by direct oxidation of sulfide. Therefore, the designed process is atom economic and represents a new “green route” for the synthesis of sulfilimines and sulfoximines.

Development of a scalable process for the crop protection agent isoclast

A scalable process to the insecticide Isoclast manufactured by Dow AgroSciences LLC is described. The process involves the de novo construction of a fully elaborated pyridine sulfide using enamine-mediated cyclization followed by two efficient and inexpensive oxidations to introduce the sulfoximine.

METHODS OF PRODUCING SULFILIMINE COMPOUNDS

Methods of producing a sulfilimine compound, such as N-cyano-S-methyl-S-[1-(6-trifluoromethyl-3-pyridinyl)ethyl]sulfilimine or other substituted sulfilimine compound. The method includes combining a sulfide compound, cyanamide, a hypochlorite compound, and a base, and oxidizing the sulfide compound to form the sulfilimine compound. The sulfide compound may include a 2-trifluoromethyl-5-(1-substituted)alkyl-thiopyridine compound. The base may include sodium hydroxide. A buffer, such as a phosphate buffer, may, optionally, be used in the reaction.