1046136-15-5Relevant academic research and scientific papers
Copper-catalyzed coupling of imidazoles and pyrazoles with 1,1-dibromo-1-alkenes: A distinct approach for direct N-alkynylation of heteroarenes
Das, Biswanath,Salvanna,Reddy, Gandolla Chinna,Balasubramanyam, Penagaluri
experimental part, p. 6497 - 6500 (2011/12/15)
The direct N-alkynylation of heteroarenes, imidazoles, and pyrazoles with 1,1-dibromo-1-alkene has been carried out for the first time using [Cu(Phen)PPh3Br] (as a catalyst) and Cs2CO3 in DMSO at 80 °C. The products are formed in good to high yields (66-85%) within 3 h. No side products could be detected.
Copper(II) oxide catalyzed ligand-free coupling reaction of heteroarenes with bromoalkynes
Das, Biswanath,Reddy, Gandolla Chinna,Balasubramanyam, Penagaluri,Salvanna
experimental part, p. 816 - 820 (2011/04/25)
The coupling reaction of imidazoles and pyrazoles with bromoacetylenes has efficiently been carried out under ligand-free conditions in the presence of copper(II) oxide as the catalyst using potassium hydroxide in 1,4-dioxane at 80 C. The method is a simpler access to N-alk-1-ynyl- and/or N-(2-bromovinyl)- substituted heteroarenes. Georg Thieme Verlag Stuttgart New York.
Coupling reactions of bromoalkynes with imidazoles mediated by copper salts: Synthesis of novel N-alkynylimidazoles
Laroche, Christophe,Li, Jing,Freyer, Matthew W.,Kerwin, Sean M.
, p. 6462 - 6465 (2008/12/22)
(Chemical Equation Presented) A cross-coupling reaction of imidazoles with bromoalkynes in the presence of a catalytic amount of CuI is reported. This protocol allows an access to novel N-(1-alkynyl)imidazoles in moderate to good yields.
