1046136-19-9

Upstream product

• 111409-79-1 1-bromo-2-(triisopropylsilyl)acetylene 
• 65020-70-4 4-(4-fluorophenyl)-1H-imidazole 

Downstream Products

• 1201526-61-5 4-(4-fluorophenyl)-2-iodo-1-(triisopropylsilanylethynyl)-1H-imidazole 

Relevant academic research and scientific papers

Synthesis and biological evaluation of p38α kinase-targeting dialkynylimidazoles

Based on the mild, thermal rearrangement of 1,2-dialkynylimidazoles to reactive carbene or diradical intermediates, a series of 1,2-dialkynylimidazoles were designed as potential irreversible p38 MAP kinase α-isoform (p38α) inhibitors. The synthesis of th

Coupling reactions of bromoalkynes with imidazoles mediated by copper salts: Synthesis of novel N-alkynylimidazoles

(Chemical Equation Presented) A cross-coupling reaction of imidazoles with bromoalkynes in the presence of a catalytic amount of CuI is reported. This protocol allows an access to novel N-(1-alkynyl)imidazoles in moderate to good yields.