1046151-33-0Relevant articles and documents
Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca2+-mobilizing activity in T-lymphocytes
Li, Lingjun,Siebrands, Cornelia C.,Yang, Zhenjun,Zhang, Liangren,Guse, Andreas H.,Zhang, Lie
scheme or table, p. 1843 - 1848 (2010/08/21)
A purine nucleobase-simplified cyclic ADP ribose (cADPR) analogue 6b was synthesized, in which a 1,2,3-triazole-4-amide was constructed, instead of a purine moiety, and the northern ribose was replaced by an ether strand. Compound 6b exhibits calcium rele
A concise route for the preparation of nucleobase-simplified cADPR mimics by click chemistry
Li, Lingjun,Lin, Baichuan,Yang, Zhenjun,Zhang, Liangren,Zhang, Lihe
, p. 4491 - 4493 (2008/09/21)
Novel nucleobase-modified cADPR mimics were synthesized by the application of click chemistry. Cu(I)-Huisgen cycloaddition (click reaction) was used to construct 4-amide-1,2,3-triazole nucleobase and connect two building blocks efficiently. A concise protection strategy was used for the synthesis of the corresponding cyclo-pyrophosphate, and the target compounds 6a and 6b were prepared within four steps.
A convenient preparation of 5-iodo-1,4-disubstituted-1,2,3-triazole: Multicomponent one-pot reaction of azide and alkyne mediated by CuI-NBS
Li, Ngjun,Zhang, Guisheng,Zhu, Anlian,Zhang, Lihe
, p. 3630 - 3633 (2008/09/20)
(Chemical Equation Presented) The system of CuI and NBS was found to provide both I+ and Cu+ for the first time. An efficient method for preparation of 5-iodo-1,4-disubstituted-1,2,3-triazole was achieved by multicomponent one-pot re
