1046152-32-2Relevant academic research and scientific papers
((((1H-INDOL-3YL) METHYLIDENE)AMINO)OXY)ACETIC ACID DERIVATIVES AND RELATED COMPOUNDS AS PAI-1 INHIBITORS FOR THE TREATMENT OF INPAIREMENT OF THE FIBRINOLYTIC SYSTEM AND OF THROMBOSIS
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Page/Page column 81, (2008/06/13)
The present invention relates to indole oxime derivatives of formula (I) wherein: R1 is -OH, -OC1-C8 alkyl, or NH2; R2and R3 are, independently, hydrogen, C1-C8 alkyl, -CH2-C3-C6 cycloalkyl, -CH2-pyridinyl, phenyl, or benzyl; R4 is hydrogen, C1-C8 alkyl, C3-C6 cycloalkyl, -CH2-C3-C6cycloalkyl, phenyl, benzyl, heteroaryl, or -CH2-heteoraryl; X is: formula (II), (III), (IV) or (V).The other substituents are defined in claim 1. The present compounds are PAI-1 inhibitors for the treatment of e.g. impairment of the fibrinolytic system, thrombosis or cardiovascular diseases.
