10463-37-3

Basic information

• Product Name: 3,5-DINITRO-4-HYDROXYPHENYLACETIC ACID
• Synonyms: 3,5-DINITRO-4-HYDROXYPHENYLACETIC ACID;3,5-dinitro-4-hydroxyphenacetic acid;4-Hydroxy-3,5-dinitrobenzeneacetic acid;4-hydroxy-3,5-dinitrophenacetic acid
• CAS NO: 10463-37-3
• Molecular Formula: C₈H₆N₂O₇
• Molecular Weight: 242.14
• Product Categories: Aromatic Phenylacetic Acids and Derivatives
• Mol File: 10463-37-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 166-168°C
• Boiling Point: 417.3 °C at 760 mmHg
• Flash Point: 184.5 °C
• Appearance: /
• Density: 1.742 g/cm³
• Vapor Pressure: 1.04E-07mmHg at 25°C
• Refractive Index: 1.676
• PKA: 3.63±0.10(Predicted)
• BRN: 2665595
• CAS DataBase Reference: 3,5-DINITRO-4-HYDROXYPHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DINITRO-4-HYDROXYPHENYLACETIC ACID(10463-37-3)
• EPA Substance Registry System: 3,5-DINITRO-4-HYDROXYPHENYLACETIC ACID(10463-37-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 10463-37-3(Hazardous Substances Data)

Usage

General Description

3,5-Dinitro-4-hydroxyphenylacetic acid, also known as 2-(3,5-dinitro-4-hydroxyphenyl)acetic acid, is a chemical compound that belongs to the class of phenylpropanoids and polyketides. It is an aromatic compound that comprises a phenylacetic acid attached to an aromatic ring bearing dinitro and hydroxy substituents in the 3,5 and 4 positions, respectively. It is commonly used in scientific research and is often utilized as a reagent or substrate in chemical reactions. Its properties, like solubility and stability, depend on its structure and can be altered under different conditions such as changes in pH, temperature, or pressure.

InChI:InChI=1/C8H6N2O7/c11-7(12)3-4-1-5(9(14)15)8(13)6(2-4)10(16)17/h1-2,13H,3H2,(H,11,12)

Upstream product

• 89723-32-0 4-Acetoxy-phenylessigsaeure-aethylester 
• 55770-69-9 3,5-Dinitro-4-hydroxy-benzylcyanid 
• 156-38-7 4-hydroxyphenylacetate 

Downstream Products

• 861065-72-7 [4-(4-methoxy-phenoxy)-3,5-dinitro-phenyl]-acetic acid ethyl ester 
• 102446-53-7 [3,5-bis-acetylamino-4-(4-methoxy-phenoxy)-phenyl]-acetic acid ethyl ester 
• 1443011-80-0 N-benzyl-2-(4-hydroxy-3,5-dinitrophenyl)acetamide 
• 1443011-77-5 N-benzyl-2-{4-hydroxy-3,5-bis[(thiophen-2-ylmethyl)amino]phenyl}acetamide 
• 1443011-83-3 C₁₅H₁₇N₃O₂ 
• 865798-49-8 (4-methoxy-3,5-dinitro-phenyl)-acetic acid methyl ester 
• 98879-76-6 methyl 2-(3,5-dinitro-4-hydroxyphenyl)acetate 
• 83799-60-4 (4-hydroxy-3,5-dinitro-phenyl)-acetic acid ethyl ester 

Relevant articles and documents

Design, synthesis, and biological evaluation of bifunctional thyrointegrin inhibitors: New anti-angiogenesis analogs

Context: Inhibition of pathological angiogenesis. Objective: Obtaining new transactivator, bifunctional, thyroid antagonist, non-toxic anti-angiogenic compounds. Materials and methods: In silico drug design, synthesis in bulk and biological evaluation in chick chorioallantoic membrane (CAM) model. Results: Significant inhibition (range 6573%) at 0.252.0 g/ml doses. Discussion and conclusion: The synthesis of compounds (9), (10), and (11) incorporating long-chain moieties guanidine, urea, methyl amine and, propyl amine substitutions, respectively, into the core molecular framework of tetrac (tetraiodothyroacetic acid) were undertaken. The evaluation of the anti-angiogenic bioactivity of these compounds in the CAM model revealed no loss of activity in comparison with tetrac and XT199, which showed nearly 86% inhibition at dose levels of 1 and 0.5 g/ml, respectively, and validated the concept.