1046454-44-7Relevant articles and documents
A Major Advance in the Synthesis of Fluoroalkyl Pyrazoles: Tuneable Regioselectivity and Broad Substitution Patterns
Schmitt, Etienne,Panossian, Armen,Vors, Jean-Pierre,Funke, Christian,Lui, Norbert,Pazenok, Sergiy,Leroux, Frédéric R.
, p. 11239 - 11244 (2016)
A novel approach towards highly functionalized fluoroalkyl pyrazoles was developed by using fluoroalkyl amino reagents in combination with a variety of fluorinated ketimines. Tuneable introduction of fluoroalkyl groups in the 3- and 5-positions was possible by using vinamidinium intermediates or the corresponding enamino ketones after hydrolysis. These high-value building blocks can give rise to a large number of analogues for bioactivity screening and discovering new heterocyclic bioactive ingredients in various life science fields.