1046460-64-3Relevant academic research and scientific papers
Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design
Liang, Gui-Bai,Qian, Xiaoxia,Biftu, Tesfaye,Singh, Suresh,Gao, Ying-Duo,Scapin, Giovanna,Patel, Sangita,Leiting, Barbara,Patel, Reshma,Wu, Joseph,Zhang, Xiaoping,Thornberry, Nancy A.,Weber, Ann E.
, p. 3706 - 3710 (2008)
Probing with tool molecules, and by modeling and X-ray crystallography the binding modes of two structurally distinct series of DPP-4 inhibitors led to the discovery of a rare aromatic fluorine H-bond and the spatial requirement for better biaryl binding in the DPP-4 enzyme active site. These newly found binding elements were successfully incorporated into novel DPP-4 inhibitors.
