1046471-30-0Relevant academic research and scientific papers
Highly efficient access to 4-chloro-2H-chromenes and 1,2-dihydroquinolines under mild conditions: TMSCl-mediated cyclization of 2-propynolphenols/anilines
Song, Xian-Rong,Li, Ren,Ding, Haixin,Yang, Ruchun,Xiao, Qiang,Liang, Yong-Min
supporting information, p. 4519 - 4524 (2016/09/23)
A novel and efficient TMSCl-mediated cyclization reaction of easily prepared 2-propynolphenols/anilines is developed to give 4-chloro-2H-chromenes and 1,2-dihydroquinolines in good to efficient yields. It is noted that TMSCl acts not only as a promoter in this reaction, and also as the chloro source. Both tertiary and secondary propargylic alcohols with diverse functional groups were tolerated under mild conditions. Moreover, this method can be enlarged to gram scale (yield up to 90%).
Highly efficient intramolecular cyclizations of 2′-hydroxychalcones to 4-chloro-2H-chromenes under Vilsmeier conditions
Li, Zhen-Hua,Zheng, Cun,Su, Wei-Ke
, p. 1195 - 1198 (2008/12/20)
(Chemical Equation Presented) Highly efficient intramolecular cyclization and of 2′-hydroxychalcones to 4-chloro-2H-chromenes under Vilsmeier conditions have been developed. In comparison with the reported methods, studies carried out indicate that Vilsme
