1046486-63-8Relevant academic research and scientific papers
Synthesis of 2-(2-imino-2,3-dihydropyrido[3,2-e]-1,3-thiazin-(Z)-4-ylidene) acetamide derivatives
Kobayashi, Kazuhiro,Iitsuka, Daisuke,Konishi, Hisatoshi
, p. 1703 - 1706 (2008)
A facile two-step preparation of the title pyridothiazine derivatives starting from commercially available 2-chloro-6-methylpyridine-3-carbonitrile is described. The reaction of this nitrile with magnesium enolates of tertiary acetamides affords (Z)-3-ami-no-3-(2-chloro-6-methylpyridin-3-yl)propenamide derivatives, which in turn are allowed to react with isothiocyanates in the presence of sodium hydride to give the desired products in satisfactory yields.
