1046494-85-2

Upstream product

• 2417-73-4 methyl 2-bromomethylbenzoate 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 1046494-86-3 2-(4-formylphenoxymethyl)benzoic acid 
• 1296209-81-8 4-amino-6-[[2-(4-formylphenoxymethyl)benzoyl]amino]-2-methylquinoline 
• 1296209-98-7 (E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(propyliminomethyl)phenoxymethyl]benzamide 
• 1296209-99-8 (E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(butyliminomethyl)phenoxymethyl]benzamide 
• 1296210-00-8 (E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(pentyliminomethyl)phenoxymethyl]benzamide 
• 1296210-01-9 (E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(hexyliminomethyl)phenoxymethyl]benzamide 
• 1296210-02-0 (E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(heptyliminomethyl)phenoxymethyl]benzamide 
• 1296210-03-1 (E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(octyliminomethyl)phenoxymethyl]benzamide 
• 1296210-04-2 (E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(nonyliminomethyl)phenoxymethyl]benzamide 
• 1296210-05-3 (E)-N-(4-amino-2-methylquinolin-6-yl)-2-[4-(decyliminomethyl)phenoxymethyl]benzamide 
• 1296210-06-4 N-(4-amino-2-methylquinolin-6-yl)-2-[4-(propylaminomethyl)phenoxymethyl]benzamide 
• 1296210-07-5 N-(4-amino-2-methylquinolin-6-yl)-2-[4-(butylaminomethyl)phenoxymethyl]benzamide 
• 1296210-08-6 N-(4-amino-2-methylquinolin-6-yl)-2-[4-(pentylaminomethyl)phenoxymethyl]benzamide 
• 1296210-09-7 N-(4-amino-2-methylquinolin-6-yl)-2-[4-(hexylaminomethyl)phenoxymethyl]benzamide 

Relevant academic research and scientific papers

Synthesis and pharmacological evaluation of bivalent antagonists of the nociceptin opioid receptor

Bivalent ligands constituted by two identical pharmacophores structurally related to the Nociceptin Opioid Receptor (NOPr) antagonist JTC-801 were synthesized and their binding affinities for NOPr were evaluated. The novel ligands are formed by two modifi

Doxepin analogs and methods of use thereof

The invention relates to novel antihistamines and methods of modulating sleep by administering a doxepin analog or a pharmaceutically effective salt thereof.

Dibenzoxepinone hydroxylamines and hydroxamic acids: Dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity

Hydroxylamine and hydroxamic acid derivatives of a known nonsteroidal antiinflammatory dibenzoxepine series display both cyclooxygenase (CO) and 5- lipoxygenase (5-LO) inhibitory properties. Many of these new dual CO/5-LO inhibitors also exhibit potent topical antiinflammatory activity in the arachidonic acid-induced murine ear edema model. On the basis of their promising profile of in vitro and in vivo activities, hydroxamic acids 24h, 3-(6,11-dihydro-11-oxodibenz[b,e]oxepin-2-yl)-N-hydroxy-N-methylpropanamide (HP 977), and 25, 3-(6,11-dihydrodibenz[b,e]oxepin-2-yl)-N-hydroxy-N- methylpropanamide (P10294), were selected as developmental candidates for the topical treatment of inflammatory skin disorders.