1046763-82-9Relevant academic research and scientific papers
Synthesis of (±)-aphanorphine: a new approach to tricyclic 3-benzazepine scaffold using two radical C-C bond-forming reactions
Yoshimitsu, Takehiko,Atsumi, Chie,Iimori, Emiko,Nagaoka, Hiroto,Tanaka, Tetsuaki
, p. 4473 - 4475 (2008/09/21)
An expeditious approach to (±)-aphanorphine has been established using readily available starting materials. The present synthesis relies on the direct assembly between N-methylpyrrolidone (NMP) and 2-bromoanisaldehyde, which takes place through Et3B/air-mediated transformation of the α-nitrogen-substituted sp3C-H bond, and features a new design concept for the synthesis of the tricyclic 3-benzazepine skeleton.
