1046791-71-2Relevant academic research and scientific papers
The first total synthesis of ganglioside GalNAc-GD1a, a target molecule for autoantibodies in guillain-barre syndrome
Fujikawa, Kohki,Nakashima, Shinya,Konishi, Miku,Fuse, Tomoaki,Komura, Naoko,Ando, Hiromune,Ando, Takayuki,Yuki, Nobuhiro,Ishida, Hideharu,Kiso, Makoto
, p. 5641 - 5651 (2011/07/08)
The first synthesis of ganglioside GalNAc-GD1a, featuring efficient glycan assembly and a cyclic glucosyl ceramide as a versatile unit for ganglioside synthesis is described. Although ganglioside GalNAc-GD1a was first found as a brain ganglioside, IgG aut
A cyclic glucosyl ceramide acceptor as a versatile building block for complex ganglioside synthesis
Fujikawa, Kohki,Nohara, Tomohiro,Imamura, Akihiro,Ando, Hiromune,Ishida, Hideharu,Kiso, Makoto
scheme or table, p. 1126 - 1130 (2010/04/23)
A cyclic glucosyl ceramide (GlcCer) acceptor has been developed as a versatile building block for the synthesis of complex ganglioside. A macrocyclic GlcCer acceptor, which was the product of intramolecular glycosylation between glucose and ceramide, exhibited high reactivity during the coupling reactions with a variety of complex oligosaccharyl donors, thereby furnishing the corresponding ganglioside frameworks in high yields.
