10468-65-2

Basic information

• Product Name: Cyclohexanol, 1-[1,1'-biphenyl]-2-yl-
• CAS NO: 10468-65-2
• Molecular Formula: C18H20O
• Molecular Weight: 252.356
• Mol File: 10468-65-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Cyclohexanol, 1-[1,1'-biphenyl]-2-yl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanol, 1-[1,1'-biphenyl]-2-yl-(10468-65-2)
• EPA Substance Registry System: Cyclohexanol, 1-[1,1'-biphenyl]-2-yl-(10468-65-2)

Safety Data

• Hazardous Substances Data: 10468-65-2(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 82214-69-5 2-biphenylmagnesium bromide 
• 2052-07-5 2-Bromobiphenyl 

Downstream Products

• 217-59-4 triphenylene 

Relevant articles and documents

Palladium-catalyzed arylation of α,α-disubstituted arylmethanols via cleavage of a C-C or a C-H bond to give biaryls

The palladium-catalyzed arylation of α,α-disubstituted arylmethanols with aryl halides proceeds not only via C-H bond cleavage at the ortho-position, but also via cleavage of the sp2-sp3 C-C bond with the liberation of ketones (β-carbon elimination) to give the corresponding biaryls. Both reactions appear to occur through common arylpalladium(II) alcoholate intermediates. The results of systematic studies with respect to which C-C or C-H bond is preferentially cleaved in the arylation are reported. Among the important findings is the selective elimination of ortho-substituted aryl groups even from aryl(diphenyl)methanols due to steric reasons. Thus, various biaryls having ortho-substituents can be produced efficiently by treatment of the corresponding aryl(diphenyl or dimethyl)methanols with aryl bromides and chlorides.