1046802-63-4Relevant academic research and scientific papers
A facile route to imidazo[1,2-a]quinolines via a domino reaction
Iminov, Rustam T.,Tverdokhlebov, Anton V.,Tolmachev, Andrey A.,Volovenko, Yulian M.,Kostyuk, Alexander N.,Chernega, Alexander N.,Rusanov, Eduard B.
, p. 1535 - 1540 (2008)
The interaction of methyl 2,4-dioxo-2H-3,1-benzoxazine-1(4H)-acetate, 1-(3,3-dimethyl-2-oxobutyl)- and 1-(2-oxopropyl)-2H-3,1-benzoxazine-2,4(1H)- diones with substituted acetonitriles, XCH2CN (X = CN, hetaryl), has been studied. In acetic acid in the presence of sodium acetate, imidazo[1,2-a]quinoline-2,5(1H,3H)-diones, 2-tert-butyl- and 2-methylimidazo[1,2-a]quinolin-5(3H)-ones were obtained in 60-85% yield. A reaction pathway is suggested and has been confirmed by the isolation of specific intermediates. The scope and limitations of the method are discussed. The structure of the obtained imidazo[1,2-a]quinoline derivatives has been assigned unambiguously on the basis of an X-ray crystallographic study. Georg Thieme Verlag Stuttgart.
