1046811-99-7

Basic information

• Product Name: 2-(3,4-Dihydro-2H-pyran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• Synonyms: 2-(3,4-Dihydro-2H-pyran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;3,4-Dihydro-2H-pyran-5-ylboronic acid, pinacol ester;3,4-Dihydro-2H-pyran-5-boronicacid,pinacolester
• CAS NO: 1046811-99-7
• Molecular Formula: C₁₁H₁₉BO₃
• Molecular Weight: 210.07776
• Mol File: 1046811-99-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 222.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.01±0.1 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-(3,4-Dihydro-2H-pyran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-Dihydro-2H-pyran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(1046811-99-7)
• EPA Substance Registry System: 2-(3,4-Dihydro-2H-pyran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(1046811-99-7)

Safety Data

• Hazardous Substances Data: 1046811-99-7(Hazardous Substances Data)

Usage

Uses

3,4-Dihydro-2H-pyran-5-ylboronic Acid Pinacol Ester is derived from Dihydro-2H-pyran-3(4H)-one (D453408), which is a general chemical reagent used in the synthesis of pharmaceuticals such as the preparation of tetrahydropyran-2-yl chromans, a highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE) inhibitor.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 73183-34-3 bis(pinacol)diborane 
• 1227068-77-0 3,4-dihydro-2H-pyran-5-yl trifluoromethanesulfonate 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 

Downstream Products

• 1227068-78-1 1H-benzimidazol-2-yl(4-((3-(5,6-dihydro-2H-pyran-3-yl)-2-pyrazinyl)oxy)phenyl)methanone 

Relevant articles and documents

PYRAZINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS

Pyrazine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

Iridium-catalyzed vinylic C-H borylation of cyclic vinyl ethers by bis(pinacolato)diboron

Vinylic C-H borylation of cyclic vinyl ethers by bis(pinacolato)diboron was effectively catalyzed by iridium complexes comprised of 1/2[Ir(OMe)(cod)] 2 and 4,4′-di-tert-butyl-2.2′-bipyridine in hexane or octane to give the corresponding vinylboron compounds in good yields. The reaction of 1,4-dioxene occurred even at room temperature, whereas the reactions of dihydropyran and dihydrofuran derivatives required a temperature above 80 °C. Although dihydropyran and dihydrofuran themselves produced regioisomeric mixtures of α- and β-borylated products, similar substrates possessing substituents at the γ-position selectively underwent borylation at the α-position. Copyright