104683-05-8Relevant academic research and scientific papers
THALLIUM IN ORGANIC SYNTHESIS. 68. A CONVENIENT SYNTHESIS OF 2-PHENYLINDOLES FROM ANILIDES
Taylor, Edward C.,Katz, Alan H.,Salgado-Zamora, Hector
, p. 5963 - 5966 (2007/10/02)
Thallation of anilides with TTFA in a mixture of TFA and ether gives ortho-thallated derivatives, which yield 2-acetamidotolanes upon reaction with copper (I) phenylacetylide in acetonitrile.Treatment of the latter compounds with palladium(II) chloride results in ring closure to give 1-acyl-2-phenylindoles, from which 2-phenylindoles are obtained by alkaline hidrolysis.
