104699-44-7

Upstream product

• 81445-44-5 (S)-2-(benzyloxy)propanal 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 673474-61-8 methyl 2-[(1R,2S)-2-(benzyloxy)-1-fluoropropyl]acrylate 
• 673474-63-0 methyl (3S,5R)-5-[(1R,2S)-2-(benzyloxy)-1-fluoropropyl]-2-methyl-3-phenyltetrahydro-5-isoxazolecarboxylate 
• 673474-62-9 methyl (3R,5R)-5-[(1R,2S)-2-(benzyloxy)-1-fluoropropyl]-2-methyl-3-phenyltetrahydro-5-isoxazolecarboxylate 

Relevant academic research and scientific papers

First 1,3-dipolar cycloaddition of Z-α-phenyl-N-methylnitrone with allylic fluorides: A stereoselective route to enantiopure fluorine-containing isoxazolidines and amino polyols

Enantiopure fluorinated isoxazolidines and amino polyols were obtained from the 1,3-dipolar cycloaddition of allylic fluorides and Z-α-phenyl-N- methylnitrone under environment-friendly conditions.

MgBr2-Promoted Addition of Heterosubstituted Methylketene Silyl Acetals to Alkoxy Aldehydes. Diastereoselective Synthesis of 3,4-Syn 2-Methylene- and 2-(Alkoxymethyl)-3-hydroxy-4-alkoxy Esters

The MgBr2-mediated addition of 2- or 3-(methylthio)-substituted ketene silyl acetals 3 and 4 to α-alkoxy and α,β-dialkoxy aldehydes, followed by oxidation and elimination of methanesulfenic acid, gave 3,4-syn 2-methylene-3-hydroxy-4-alkoxy esters 9 and 11 with very high stereoselectivity (up to 100:1) and in good chemical yields.The same diastereofacial selection is at work in the analogous additions of ketene methyl silyl acetal 5, which affords 3,4-syn 2--3-hydroxy-4-alkoxy esters 12-15.