1047-77-4Relevant academic research and scientific papers
TRICYCLIC AMINO CONTAINING COMPOUNDS FOR TREATMENT OR PREVENTION OF SYMPTOMS ASSOCIATED WITH ENDOCRINE DYSFUNCTION
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Page/Page column 51; 52; 59, (2013/05/23)
The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.
Room temperature tandem hydroamination and hydrosilation/protodesilation catalysis by a tricarbonylchromium-bound iridacycle
Iali, Wissam,Paglia, Frederic La,Pfeffer, Michel,Djukic, Jean-Pierre,Goff, Xavier-Frederic Le,Sredojevic, Dusan
, p. 10310 - 10312,3 (2012/12/11)
A chromiumtricarbonyl-bound iridacycle displays novel catalytic virtues for the conversion of terminal aromatic alkynes into racemic N-phenyl, 1-arylethylamines by tandem hydro-amination and hydrosilation/protodesilation reactions under mild "one pot" con
Discovery of small molecule CXCR4 antagonists
Zhan, Weiqiang,Liang, Zhongxing,Zhu, Aizhi,Kurtkaya, Serdar,Shim, Hyunsuk,Snyder, James P.,Liotta, Dennis C.
, p. 5655 - 5664 (2008/03/17)
In light of a proposed molecular mechanism for the C-X-C chemokine receptor type 4 (CXCR4) antagonist 1 (AMD3100), a template with the general structure 2 was designed, and 15 was identified as a lead by means of an affinity binding assay against the liga
CXCR4 ANTAGONISTS FOR THE TREATMENT OF HIV INFECTION
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Page/Page column 63, (2008/06/13)
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor, and in particular to inhibit viral entry of certain viruses. Certain compounds in particular can reduce entry of immunodeficiency virus (HIV) into a cell while not reducing the capacity of stem cells to proliferate, and therefore can be useful for long term treatment regimes. The compounds are useful in particular in the treatment or prevention of HIV infections.
Antioxidant for polyester fluids - alpha - methyl - n phenylbenzenemethanamine
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, (2008/06/13)
An antioxidant for lubricating oils comprising an amine compound selected from substituted benzylamines or a substituted 1-amino-1,2,3,4-tetrahydro-naphthalene. The preferred anti-oxidants are N-(alpha -methyl -p -octylbenzyl) aniline, N-(alpha-methylbenz
