104705-40-0Relevant articles and documents
Selective activity against Mycobacterium tuberculosis of new quinoxaline 1,4-di-N-oxides
Vicente, Esther,Pérez-Silanes, Silvia,Lima, Lidia M.,Ancizu, Saioa,Burguete, Asunción,Solano, Beatriz,Villar, Raquel,Aldana, Ignacio,Monge, Antonio
, p. 385 - 389 (2009)
New series of 3-phenylquinoxaline 1,4-di-N-oxide with selective activity against Mycobacterium tuberculosis have been prepared and evaluated. Thirty-four of the seventy tested compounds showed an MIC value less than 0.2 μg/mL, a value on the order of the
Comparative use of solvent-free KF-Al2O3 and K 2CO3 in acetone in the synthesis of quinoxaline 1,4-dioxide derivatives designed as antimalarial drug candidates
Lima,Zarranz,Marin,Solano,Vicente,Perez Silanes,Aldana,Monge
, p. 1381 - 1385 (2005)
In this paper we describe two new basic conditions for the synthesis of quinoxaline 1,4-dioxide derivatives in moderate to good yields. These conditions, exemplified by the use of K2CO3 in acetone or KF/Al2O3 in
A new facile, efficient synthesis and structure peculiarity of quinoxaline derivatives with two benzimidazole fragments
Mamedov, Vakhid A.,Zhukova, Nataliya A.,Syakaev, Victor V.,Gubaidullin, Aidar T.,Beschastnova, Tat'Yana N.,Adgamova, Dil'Bar I.,Samigullina, Aida I.,Latypov, Shamil K.
supporting information, p. 1403 - 1416 (2013/02/23)
A highly efficient and versatile method for the synthesis of quinoxaline derivatives with two benzimidazole fragments have been developed on the basis of the ring contraction of 3-(benzimidazo-2-yl)quinoxalin-2(1H)-one with 1,2-diaminobenzene and its various types of substituted and condensed derivatives. Owing to the inter- and intramolecular processes, involving self association, proton exchange, conformational, and/or tautomeric exchanges between several forms for most of the bis-benzimidazolylquinoxalines signals of bridged and neighboring carbon atoms and the hydrogen atoms of the neighboring carbon atoms of benzimidazole fragments in the NMR spectra are broadened. The conjugation between the benzimidazole fragments and the quinoxaline core of the molecules is increased from the quinoxaline derivative (10c) to its thiadiazol[f]- (17) and pyrrolo[a]-(19) annulated derivatives, resulting in a greater planarity of the molecule as a whole.
The reactions of benzofuroxan with carbonyl compounds on the surface of solid catalysts
Takabatake,Hasegawa,Hasegawa
, p. 1477 - 1480 (2007/10/02)
The cyclocondensations of benzofuroxan 1a with carbonyl compounds were smoothly and efficiently carried out by the adsorption of the components on the surface of silica gel or a molecular sieve to form a 2,3-disubstituted quinoxaline 1,4-dioxide. When the
A New Synthesis of 2,3-Disubstituted Quinoxaline 1,4-Dioxide Catalyzed by Molecular Sieves
Takabatake, Tohru,Hasegawa, Minoru
, p. 529 - 530 (2007/10/02)
The syntheses of 2,3-disubstituted quinoxaline 1,4-dioxides are smoothly and efficiently carried out by the adsorption of the components on molecular sieve 3A (powder) from benzofuroxan 1 and 1,3-diketones, 3-oxoalkanoic esters, or 3-oxoalkanamides 2.
Reactions of Benzofuroxan with 1,3-Diketones or β-Ketoesters on Silica Gel or Alumina
Hasegawa, Minoru,Takabatake, Tohru
, p. 938 (2007/10/02)
The cyclocondensation of benzofuroxan with 1,3-diketones, 3-oxoalkanoic esters, butanedioic esters, or 3-oxoalkanamides in the presence of silica gel (adsorption of the components on silica gel) represents a convenient method for the synthesis of 2,3-disu
