1047082-32-5Relevant academic research and scientific papers
Ruthenium-catalyzed enantioselective carbon-carbon bond forming reaction via allenylidene-ene process: Synthetic approach to chiral heterocycles such as chromane, thiochromane, and 1,2,3,4-tetrahydroquinoline derivatives
Fukamizu, Koji,Miyake, Yoshihiro,Nishibayashi, Yoshiaki
supporting information; experimental part, p. 10498 - 10499 (2009/02/05)
Our previously disclosed ruthenium-catalyzed carbon-carbon bond forming reactions between propargylic alcohols and alkenes via an allenylidene-ene type pathway have been successfully applied to an enantioselective intramolecular cyclization for a variety of chiral heterocycles such as chromane, thiochromane, and 1,2,3,4-tetrahydroquinoline derivatives (up to 99% ee) by use of a suitable optically active diruthenium complex as a catalyst. The methodology described in this paper becomes a novel synthetic approach to chiral heterocycles, the structures of which are widely found in many natural and biologically active compounds. Copyright
