10471-65-5Relevant academic research and scientific papers
A new paradigm for biohydroxylation by Beauveria bassiana ATCC 7159
Holland, Herbert L.,Morris, Terence A.,Nava, Phillip J.,Zabic, Mirjana
, p. 7441 - 7460 (2007/10/03)
The biohydroxylation of a series of amides and related amino, keto and hydrocarbon substrates by the fungal biocatalyst Beauveria bassiana ATCC 7159 has been examined. The product distributions, together with data obtained from selective inhibition experiments using the cyt.P-450 inhibitors isosafrole, 1-aminobenzotriazole and phenylacetylene, suggest that B. bassiana contains a range of hydroxylase enzymes with different substrate specificities. A paradigm is presented for the interpretation of the results of microbial hydroxylation and for the application of existing active site models for B. bassiana.
Potential antiinflammatory compounds. I. Antiinflammatory phenylpiperidine derivatives
Hicks,Smith,Williamson,Day
, p. 1460 - 1464 (2007/10/05)
The syntheses of a number of amines and their derivatives, based on the phenylpiperidine nucleus, are described. Their activities on the rat paw carrageenan test are also reported. Activities comparable to that of phenylbutazone were obtained for some of
