104712-44-9 Usage
Uses
1. Used in Pharmaceutical Industry:
(6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetylamino]-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid pivaloyloxymethyl ester is used as an intermediate in the synthesis of various pharmaceutical compounds, particularly those belonging to the cephalosporin class of antibiotics. Its role in the synthesis process is crucial for the development of effective treatments for bacterial infections.
2. Used in Research and Development:
(6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetylamino]-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid pivaloyloxymethyl ester is also utilized in research and development settings to study its chemical properties, potential applications, and interactions with other molecules. Understanding its behavior and reactivity can lead to the discovery of new drugs and therapeutic agents.
3. Used in Quality Control and Analysis:
As a minor metabolite of Cefteram Pivoxil, (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetylamino]-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid pivaloyloxymethyl ester is essential for quality control and analysis in the pharmaceutical industry. It helps ensure the purity, potency, and safety of the final drug product by serving as a reference compound in various analytical techniques.
Check Digit Verification of cas no
The CAS Registry Mumber 104712-44-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,7,1 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 104712-44:
(8*1)+(7*0)+(6*4)+(5*7)+(4*1)+(3*2)+(2*4)+(1*4)=89
89 % 10 = 9
So 104712-44-9 is a valid CAS Registry Number.
InChI:InChI=1/C22H27N9O7S2/c1-10-26-29-30(27-10)6-11-7-39-18-14(25-16(32)13(28-36-5)12-8-40-21(23)24-12)17(33)31(18)15(11)19(34)37-9-38-20(35)22(2,3)4/h7-8,14-15,18H,6,9H2,1-5H3,(H2,23,24)(H,25,32)/b28-13+/t14-,15?,18-/m1/s1
104712-44-9Relevant academic research and scientific papers
Saab,Hussain,Patel,Dittert
, p. 802 - 805 (1990)
The delta-3 and delta-2 methyl esters of cefazolin were synthesized. The kinetics and mechanisms of degradation of the methyl esters and the delta-3 and delta-2 isomers of pivaloxymethyl prodrug esters of the new cephalosporin ceftetrame (Ro 19-5247) were investigated in buffer systems and in human plasma in vitro. The major hydrolytic products of all the delta-3 and delta-2 esters were the inactive delta-2 cephalosporin free acids. In addition, there was evidence of opening of the β-lactam ring to form cephalosporoic acid when the methyl ester of cefazolin was studied in human plasma and in the presence of penicillinase. For the methyl esters, the processes represented by k12, k21, and k20 were operative in buffers; in human plasma, the processes represented by k12, k21, and k20 were operative in addition to cephalosporoic acid formation. For the isomers of the cephalosporin prodrug ester Ro 19-5248 only k12 and k20 were operative in buffers; in human plasma all pathways were operative and there was no evidence of cephalosporoic acid formation. In all cases, the processes represented by k12, k21, and k20 were subject to general and/or specific base catalysis.
