10472-88-5

Basic information

• Product Name: 2-BROMO-4-FLUORO-6-NITROANILINE
• Synonyms: 2-BROMO-4-FLUORO-6-NITROANILINE;2-Bromo-4-fluoro-6-nitroaniline 98%;2-Bromo-4-fluoro-6-nitroaniline98%;2-Amino-3-bromo-5-fluoronitrobenzene;BenzenaMine, 2-broMo-4-fluoro-6-nitro-;2-bromo-4-fluoro-6-nitrobenzenamine
• CAS NO: 10472-88-5
• Molecular Formula: C₆H₄BrFN₂O₂
• Molecular Weight: 235.01
• EINECS: 1533716-785-6
• Product Categories: Amines;Phenyls & Phenyl-Het
• Mol File: 10472-88-5.mol
• Article Data: 16

Chemical Properties

• Melting Point: 70-72°C
• Boiling Point: 313.9 °C at 760 mmHg
• Flash Point: 143.6 °C
• Appearance: Orange/Powder
• Density: 1.896 g/cm³
• Vapor Pressure: 0.000483mmHg at 25°C
• Refractive Index: 1.641
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-BROMO-4-FLUORO-6-NITROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-FLUORO-6-NITROANILINE(10472-88-5)
• EPA Substance Registry System: 2-BROMO-4-FLUORO-6-NITROANILINE(10472-88-5)

Safety Data

• Hazard Codes: T
• HazardClass: 6.1
• Hazardous Substances Data: 10472-88-5(Hazardous Substances Data)

Usage

Chemical Properties

off-white powder

Uses

2-Bromo-4-fluoro-6-nitroaniline is used as pharmaceutical intermediate.

InChI:InChI=1/C6H4BrFN2O2/c7-4-1-3(8)2-5(6(4)9)10(11)12/h1-2H,9H2

Upstream product

• 364-78-3 2-nitro-4-fluoroaniline 

Downstream Products

• 144580-08-5 2-Iodo-3-bromo-5-fluoroaniline 
• 144580-17-6 1-iodo-2-nitro-4-fluoro-6-bromobenzene 
• 1312923-89-9 3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitrofluorobenzene 
• 934162-32-0 2,3-diamino-5-fluorobenzamide 
• 936551-84-7 2-amino-5-fluoro-3-nitrobenzamide 
• 1245642-98-1 4-bromo-6-fluoro-1H-benzo[d]imidazole 
• 115440-10-3 3-bromo-5-fluoro-1,2-phenylenediamine 
• 912444-99-6 2-amino-5-fluoro-3-nitrobenzonitrile 
• 7087-65-2 1-bromo-3-fluoro-5-nitrobenzene 

Relevant articles and documents

Directed biosynthesis of 5'-fluoropactamycin in Streptomyces pactum

A new pactamycin analogue, 5'-fluoropactamycin, was prepared by directed biosynthesis. Supplementation of the fermentation medium of Streptomyces pactum, var. pactum with 3-amino-5-fluorobenzoic acid, an analogue of 3-aminobenzoic acid, an advanced precursor in pactamycin biosynthesis, resulted in co-production of pactamycin and the new pactamycin analogue. A similar feeding experiment with 3-amino-5-methylbenzoic acid did not result in formation of the corresponding methylated pactamycin analogue, but only in inhibition of pactamycin production. Comparison of antimicrobial and cytotoxic activities of pactamycin and 5'-fluoropactamycin showed no significant differences.

Fluorine atom substituted benzo heterocycle based conjugated molecule material as well as preparation method and application thereof

The invention discloses a fluorine atom substituted benzo heterocycle based conjugated molecule material as well as a preparation method and application thereof. The conjugated molecule material is ofan acceptor-donor-acceptor type structure, wherein an a

Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted- phenyl series

We report the synthesis of four series of 3,5-disubstituted-phenyl ligands targeting the metabotropic glutamate receptor subtype 5: (2-methylthiazol-4-yl) ethynyl (1a-j,), (6-methylpyridin-2-yl)ethynyl (2a-j), (5-methylpyridin-2-yl) ethynyl (3a-j,), and (pyridin-2-yl)ethynyl (4a-j,). The compounds were evaluated for antagonism of glutamate-mediated mobilization of internal calcium in an mGluR5 in vitro assay. All compounds were found to be full antagonists and exhibited low nanomolar to subnanomolar activity.