104726-86-5Relevant academic research and scientific papers
SILYLAMINES IN ORGANIC SYNTHESIS : A NEW ACCESS TO FUNCTIONAL PYRROLES VIA ORGANOCUPRATES ADDITION ON METHYL-BIS(TRIMETHYLSILYL)AMINOMETHYLPROPIOLATE
Corriu, Robert J.P.,Moreau, Joel J.E.,Vernhet, Claude
, p. 2963 - 2966 (1987)
Organocuprate addition reactions on methyl-bis(trimethylsilyl)aminomethylpropiolate lead to the formation of a Z-vinyl cuprate with a high stereoselectivity.Upon reaction of acid chloride, pyrroles are formed by a spontaneous intramolecular cyclisation of the intermediate Z-silylamino enone.Various functional substituted pyrroles can be obtained in one step by this route.
Aminosilanes in Organic Synthesis. Addition of Organocopper Reagents on γ-Bis(trimethylsilyl)amino-α-Acetylenic Amides, Esters and Ketones. Stereochemistry und Some Synthetic Uses
Corriu, Robert J. P.,Bolin, Geng,Iqbal, Javed,Moreau, Joel J. E.,Vernhet, Claude
, p. 4603 - 4618 (2007/10/02)
The stereochemical outcome of the carbocupration of γ-bis(trimethylsilyl)amino-α-acetylenic amide, esters and ketone was studied.A judicious choice of substrate, reagent and(or) reaction conditions allows to perform highly stereoselective cis or trans addition.The intermediate vinylic copper adducts, with (E) or (Z) configuration, react with electrophilic reagents to provide short routes to substituted pyrrolinones and pyrroles.Keywords: Silylamines, propargylamines, organocopper regaents, stereochemistry, nitrogen heterocycles.
The Chemistry of Pyrrolic Compounds.LVIII meso-Substituted Porphyrins : Further Observations on the Oxidative Cyclization of Bilenes-b
Clezy, Peter S.,Duncan, Mark W.,Ravi, B.N.,Thuc, Le van
, p. 399 - 418 (2007/10/02)
The oxidative cyclization of series of bilenes-b carrying substituted methyl groups at a terminal site (1d-i) hes been investigated as an approach to the synthesis of meso-substituted porphyrins.Although in most cases the required porphyrin was formed the
