104730-53-2Relevant academic research and scientific papers
Formation of Optically Active Aryloxyacetaldehyde Cyanohydrin Acetates with the Aid of a Microorganism
Ohta, Hiromichi,Miyamae, Yoshitaka,Tsuchihashi, Gen-ichi
, p. 215 - 222 (2007/10/02)
Microorganisms that hydrolyze the one enantiomer of dl-phenoxyacetaldehyde cyanohydrin acetate were screened, and Bacillus coagulans isolated from soil was found to be the best.This bacterium was applied to the asymmetric hydrolysis of other aryloxyacetaldehyde derivatives to give satisfactory results.The effect of adding dimethyl sulfoxide to the medium is also described.
PREPARATION OF OPTICALLY ACTIVE 1-ACETOXY-2-ARYLOXYPROPIONITRILES AND ITS APPLICATION TO A FACILE SYNTHESIS OF (S)-(-)-PROPRANOLOL
Matsuo, Noritada,Ohno, Nobuo
, p. 5533 - 5534 (2007/10/02)
(S)-1-Acetoxy-2-aryloxypropionitriles were synthesized by an asymmetric hydrolysis of the racemates with an enzyme. (S)-Propranolol, a typical β-adrenergic blocker, was synthesized from (S)-1-acetoxy-2-α-naphthyloxypropionitrile in two steps.
