104732-95-8Relevant academic research and scientific papers
Tritium Nuclear Magnetic Resonance Spectroscopy of Bepridil
Kaspersen, Frans M.,Funke, Carel W.,Sperling, Eric M. G.,Rooy, Fons A. M. van,Wagenaars, Gerard N.
, p. 585 - 592 (2007/10/02)
Bepridil tritiated in the pyrrolidine ring by reduction of the 2,5-dihydropyrrol-1-yl analogue with tritium shows a complicated (1)H-decoupled (3)H n.m.r. spectrum.With the aid of isotopic fractionation by h.p.l.c. this spectrum could be interpreted as a sum of the spectra of various mono-, di-, and tri-tritiated diastereomers.In the case of the (+)-(R)-isomer of bepridil the optical purity could be determined by (3)H n.m.r. in the presence of Pirkle's alcohol.
