104746-25-0Relevant academic research and scientific papers
Mechanism of the CuCl/O2-mediated Oxygenation of Naphtholes
Duchstein, Hans-Juergen,Mueller, Klaus,Wurm, Gotthard
, p. 153 - 157 (1988)
The mechanism of the oxygenation of 1- and 2-naphthole derivatives in the system (1+) + O2 .>(1) + L, depending on solvent (L) and temp., is studied.It was possible to distinguish between reactions via the radical ion pair type (L=CH3CN) and hydrogen abstraction via free radicals (L=CH3OH).There is marked difference between the oxygen transfer to the naphthole derivatives and the oxygenation of 2,6-di-tert-butylphenol (6), which does not depend characteristically on L and temp.
A new class of phenazines with activity against a chloroquine resistant plasmodium falciparum strain and antimicrobial activity
Hussain, Hidayat,Specht, Sabine,Sarite, Salem R.,Saeftel, Michael,Hoerauf, Achim,Schulz, Barbara,Krohn, Karsten
supporting information; experimental part, p. 4913 - 4917 (2011/09/15)
New phenazines were synthesized by oxygenation of 1- and 2-naphthol with transition metal peroxo complexes and in situ reaction with 1,2-diamines. The title compounds were evaluated for in vitro antimalarial activity against Plasmodium falciparum and chloroquine-resistant strains. Phenazines 12, 27, and 28 were most prominent in growth inhibition. In vivo protection against cerebral malaria was observed with the phenazines 11, 12, 20, and 27, whereas partial protection was provided by 19.
An evaluation of some hindered diamines as chiral modifiers of metal-promoted reactions
Illesinghe, Jayamini,Ebeling, Richard,Ferguson, Brett,Patel, Jim,Campi, Eva M.,Jackson, W. Roy,Robinson, Andrea J.
, p. 167 - 176 (2007/10/03)
Diamino analogues of the C2-symmetric chiral diphosphine ligands DuPHOS and BPE have been prepared and evaluated as chiral modifiers of the osmium tetraoxide dihydroxylation of stilbene. NMR experiments showed that these ligands were too bulky to coordinate to osmium. Less hindered analogues of these ligands were prepared and some were shown to act as ligands in dihydroxylation reactions but with poor enantioselectivity (e.e. 10%). The diamines have also been briefly evaluated as ligands in rhodium-catalyzed hydroformylation and copper-catalyzed phenolic coupling reactions. Once again, only low enantioselectivity was obtained.
