10475-15-7

Upstream product

• 110-86-1 pyridine 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 94-41-7 benzalacetophenone 

Downstream Products

• 90361-87-8 trans-3,4-dihydro-2-hydroxymethyl-2,4-diphenyl-2H,5H-pyrano<3,2-c><1>benzopyran-5-one 
• 90361-89-0 (2R,4S)-2-Hydroxymethyl-2,4-diphenyl-3,4-dihydro-2H-pyrano[2,3-b]chromen-5-one 
• 92824-16-3 4-hydroxy-3-(1,3-diphenyl-3-butenyl)-2H-1-benzopyran-2-one 
• 1342296-37-0 2,4-diphenyl-4H-thiopyrano[3,2-c]chromen-5-one 

Relevant academic research and scientific papers

Reaction between Chalcones, 1,3-Dicarbonyl Compounds, and Elemental Sulfur: A One-Pot Three-Component Synthesis of Substituted Thiophenes

A simple and atom-economic synthesis of highly substituted thiophenes is demonstrated. Heating a solution of a chalcone and a linear/cyclic 1,3-dicarbonyl compound with elemental sulfur in CH 3 CN in the presence of NEt 3 at 80 °C af

Base-controlled selective construction of polysubstituted dihydrofuran and furan derivatives through an I2-mediated cyclization

A base-controlled formal [3?+?2] cycloaddition of 1,3-dicarbonyl compounds to enones via an I2-mediated cyclization was reported. Highly functionalized dihydrofurans and furans were selectively obtained under I2/DMAP and I2/sub

Hypoiodite-catalysed oxidative cyclisation of Michael adducts of chalcones with 1,3-dicarbonyl compounds: A facile and versatile approach to substituted furans and cyclopropanes

Through hypoiodite catalysis, oxidative cyclisation of Michael adducts of chalcones with 1,3-dicarbonyl compounds for divergent synthesis of either furans or cyclopropanes is developed. The selective synthesis of major products is achieved depending on the use of different reaction conditions or substrates.

Synthesis and pharmacological investigations of some 4-hydroxycoumarin derivatives

The synthesis of ten coumarin derivatives of 4-hydroxycoumarin and various unsaturated ketones and aldehydes is described. The structures of the synthesized compounds were confirmed by IR, 1H-NMR, and mass-spectral data. Acute toxicity studies of the compounds were performed on mice by oral and intraperitoneal administration. A comparative pharmacological study of the in vivo anticoagulant effects of the derivatives with respect to warfarin, showed that the compounds have anticoagulant activity. Compounds 4-hydroxy-3-[1-phenyl-2-(4′-chlorobenzoyl)-ethyl]-2H-1-benzopyran-2-one 2b, 4-hydroxy-3-[1-(4-fluorophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one 3a, and 3,3′-p-bromobenzylidene-bis-(4-hydroxy-2H-1-benzopyran-2-one) 4 b showed slight acute toxicity and a greater anticoagulant effect than warfarin.