104750-64-3Relevant academic research and scientific papers
PALLADIUM CATALYZED REACTIONS OF PROPIONATE HOMOENOLATE. ARYLATION, VINYLATION, AND ACYLATION
Nakamura, Eiichi,Kuwajima, Isao
, p. 83 - 86 (1986)
Zinc homoanolate of alkyl propionate undergoes clean C-C bond forming reactions with aryl, vinyl and acid halides in the presence of a palladium catalyst.
Carbon-Carbon Bond-Forming Reactions of Zinc Homoenolate of Esters. A Novel Three-Carbon Nucleophile with General Synthetic Utility
Nakamura, Eiichi,Aoki, Satoshi,Sekiya, Kouichi,Oshino, Hiroji,Kuwajima, Isao
, p. 8056 - 8066 (2007/10/02)
In the presence of suitable catalysts and additives, the zinc homoenolate of alkyl propionate and its congeners undergo a variety of carbon-carbon bond-forming reactions, e.g., addition onto carbonyl compounds, allylation, arylation, vinylation, and acylation, to produce diverse kinds of alkanoates and cyclopropane derivatives.The moderately reactive zinc homoenolate exhibited a very high degree of chemoselectivity in these reactions.Me3SiCl has been found to greatly accelerate 1,2- or 1,4-addition and the allylation reaction of the zinc reagent.
