104756-60-7Relevant academic research and scientific papers
One-pot cyclization of 2-aminophenethyl alcohols: A novel and direct approach to the synthesis of N-acyl indolines
Wang, Zengxue,Wan, Wen,Jiang, Haizhen,Hao, Jian
, p. 9364 - 9367 (2008/03/13)
(Chemical Equation Presented) A unique one-pot cyclization of 2-aminophenethyl alcohols with carboxylic acids in the presence of PPh 3, CCL4, and NEt3 furnished the formation of N-acyl indolines in good to excellent yields. This new approach provides an efficient, scalable, low-cost, and direct access to the biologically important indolines which are further oxidizable to indoles and oxindoles.
