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1047645-80-6

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1047645-80-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1047645-80-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,7,6,4 and 5 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1047645-80:
(9*1)+(8*0)+(7*4)+(6*7)+(5*6)+(4*4)+(3*5)+(2*8)+(1*0)=156
156 % 10 = 6
So 1047645-80-6 is a valid CAS Registry Number.

1047645-80-6Relevant articles and documents

AFURESERTIB: Protein kinase B (PKB) inhibitor Oncolytic

Conkel,Benson

, p. 541 - 546 (2014/12/11)

The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway plays key roles in cellular proliferation and survival. Mutations and alterations in this signal transduction pathway have been described in a variety of solid and hematopoietic malignancies, which may contribute to perpetuation of the disease in a number of ways. Increasing interest in targeting particular facets of this signaling cascade has led to the development of a number of novel anticancer agents, including afuresertib (GSK-2110183), an orally bioavailable pan-inhibitor of the RAC-alpha serine/threonine protein kinase, also referred to as protein kinase B or proto-oncogene c-Akt. The present review summarizes the preclinical and pharmacological aspects of afuresertib and early clinical experience.

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