1047659-02-8

Basic information

• Product Name: Entacapone (sodiuM salt)
• Synonyms: Entacapone (sodiuM salt);Entacapone Sodium
• CAS NO: 1047659-02-8
• Molecular Formula: C₁₄H₁₄N₃O₅*Na
• Molecular Weight: 329.29
• Mol File: 1047659-02-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Entacapone (sodiuM salt)(CAS DataBase Reference)
• NIST Chemistry Reference: Entacapone (sodiuM salt)(1047659-02-8)
• EPA Substance Registry System: Entacapone (sodiuM salt)(1047659-02-8)

Safety Data

• Hazardous Substances Data: 1047659-02-8(Hazardous Substances Data)

Upstream product

• 130929-57-6 entacapone 
• 145195-63-7 (2Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide 

Relevant articles and documents

PROCESS FOR PREPARING ENTACAPONE SUBSTANTIALLY FREE OF Z-ISOMER, SYNTHESIS INTERMEDIATES THEREOF AND A NEW CRYSTALLINE FORM

The present invention relates to a new process for preparing Entacapone substantially free of Z-isomer from 3, 4-dihydroxy-5-Nitrobenzaldehyde and N, N-Dimethylcyano acetamide, or directly from a mixture of (E) - and (Z) - isomers of Entacapone, by formation of organic or inorganic salts, specially piperidine and sodium ones. A new crystalline form G of Entacapone can be obtained from this method in a fast, efficient, and simple way and substantially free of Z-isomer. Another object of the invention is a pharmaceutical composition comprising it.