1047683-33-9Relevant academic research and scientific papers
Unexpected effect of the fluorine atom on the optimal ligand-to-palladium ratio in the enantioselective Pd-catalyzed allylation reaction of fluorinated enol carbonates
Belanger, Etienne,Houze, Clement,Guimond, Nicolas,Cantin, Katy,Paquin, Jean-Francois
, p. 3251 - 3253 (2008)
The enantioselective Pd-catalyzed allylation reaction of fluorinated allyl enol carbonates is presented; a key feature of this transformation is the important effect of the ligand-to-palladium ratio on the enantioselectivity of the α-fluoroketones, since using a ligand excess (L/Pd ratio = 1.25: 1) led to moderate results (30-76% ee), while using a L/Pd ratio 1: 1.67 (to as low as 1: 4) allowed the desired products to be obtained with high enantiopurity (up to 94% ee). The Royal Society of Chemistry.
