104772-90-9Relevant academic research and scientific papers
Carbapenem compounds and production thereof
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, (2008/06/13)
A compound of the formula: STR1 wherein R1 is a hydrogen atom or a lower alkyl group, R2 is a hydrogen atom or a conventional protecting group for a carboxyl group, R0 is a hydrogen atom or a conventional protecting group for a hydroxyl group, X is a protected or unprotected amino group, a carboxyl group, a lower alkoxycarbonyl group, an ar(lower)alkyloxycarbonyl group, a cyano group, a hydroxyl group, a lower alkyloxy group, a lower alkylthio group, a lower alkylsulfonyl group or a group of either one of the following formulas: STR2 wherein R3 and R4, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, or they are taken together to represent an alkylene chain to form, in combination with the adjacent nitrogen atom, a 3- to 7-membered cyclic amino group, wherein Z represents --NH-- or --O-- and R5 represents an amino group, a mono(lower)alkylamino group, a di(lower)alkylamino group, a lower alkyloxy group or a lower alkyl group, STR3 wherein R6 represents a hydrogen atom or a lower alkyl group, wherein R7 represents a mono(lower)alkylamino group, a di(lower)alkylamino group or a lower alkyloxy group, or STR4 wherein R8, R9 and R10, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, Y represents a hydrogen atom, a conventinal protecting group for an amino group or a group of either one of the following formulas: STR5 wherein R11 and R12, which may be the same or different, each represents a hydrogen atom or a lower alkyl group or STR6 wherein R6 is as defined above and n is an ingeter of 1 to 6, and a pharmacologically acceptable salt thereof, which is useful as an antimicrobial agent.
