104777-61-9

Basic information

• Product Name: 3alpha-Akeboic acid
• Synonyms: 3alpha-Akeboic acid;3alpha-Akebonoic acid;3-Epiakebonoic acid;(3alpha)-3-Hydroxy-30-noroleana-12,20(29)-dien-28-oic acid
• CAS NO: 104777-61-9
• Molecular Formula: C29H44O3
• Molecular Weight: 440.65786
• Mol File: 104777-61-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3alpha-Akeboic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3alpha-Akeboic acid(104777-61-9)
• EPA Substance Registry System: 3alpha-Akeboic acid(104777-61-9)

Safety Data

• Hazardous Substances Data: 104777-61-9(Hazardous Substances Data)

Usage

General Description

3alpha-Akeboic acid is a naturally occurring triterpenoid compound found in plants such as Senecio vulgaris. It exhibits a variety of biological activities including anti-tumor, anti-inflammatory, and anti-diabetic properties. Research has shown that 3alpha-Akeboic acid can inhibit the growth of cancer cells and induce apoptosis, making it a potential candidate for cancer treatment. Additionally, it has been found to have anti-inflammatory effects by inhibiting the production of inflammatory mediators. Furthermore, studies have also demonstrated its potential in regulating blood sugar levels and improving insulin sensitivity, suggesting its potential use in the treatment of diabetes. Overall, the diverse pharmacological properties of 3alpha-Akeboic acid make it a promising candidate for further research and potential therapeutic applications.

Upstream product

• 114906-73-9 ciwujianoside C₁ 
• 102719-83-5 3-O-<α-L-arabinopyranosyl>-30-norolean-12,20(29)-dien-28-oic acid 
• 114892-56-7 ciwujianoside C₂ 
• 114892-57-8 ciwujianoside D₂ 
• 1169768-86-8 3-O-(β-D-xylopyranosyl-(1->3)-[α-L-rhamnopyranosyl-(1->2)]-α-L-arabinopyranosyl)akebonic acid 28-O-(α-L-rhamnopyranosyl-(1->4)-β-D-glucopyranosyl-(1->6)-β-D-glucopyranosyl) ester 
• 1169768-87-9 3-O-(β-D-galactopyranosyl-(1->2)-α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranosyl)akebonic acid 28-O-(α-L-rhamnopyranosyl-(1->4)-β-D-glucopyranosyl-(1->6)-β-D-glucopyranosyl) ester 
• 18598-63-5 L-cysteine methyl ester hydrochloride 

Relevant articles and documents

Triterpenoid saponins and phenylethanoid glycosides from stem of Akebia trifoliata var. australis

A detailed phytochemical study on the 70% aqueous ethanol extract of stems of Akebia trifoliata (Thunb.) Koidz. var. australis (Diels) Rehd led to isolation of five compounds, together with 12 known triterpenoid saponins and three known phenylethanoid glycosides. The structures of the five compounds were elucidated on the basis of analysis of spectroscopic data and physicochemical properties as: 2α, 3β, 23-trihydroxy-30-norolean-12-en-28-oic acid β-d-glucopyranosyl ester (1), 2α, 3β, 23-trihydroxy-30-norolean-12-en-28-oic acid β-d-xylopyranosyl-(1 → 3)-O-α-d-rhamnopyranosyl-(1 → 4)-O-β-d-glucopyranosyl-(1 → 6)-O-β-d-glucopyranosyl ester (2), 2α, 3β, 23-trihydroxyurs-12-en-28-oic acid β-d-xylopyranosyl-(1 → 3)-O-α-l-rhamnopyranosyl-(1 → 4)-O-β-d-glucopyranosyl-(1 → 6)-O-β-d-glucopyranosyl ester (3), 3-β-[(β-d-glucopyranosyl-(1 → 3)-O-α-l-arabinopyranosyl)oxy]-23-hydroxy-30-norolean-12-en-28-oic acid α-l-rhamnopyranosyl-(1 → 4)-O-β-d-glucopyranosyl-(1 → 6)-O-β-d-glucopyranosyl ester (4) and 3-β-[(α-l-xylopyranosyl-(1 → 2)-O-α-l-arabinopyranosyl)oxy]-30-norolean-12-en-28-oic acid α-l-rhamnopyranosyl-(1 → 4)-O-β-d-glucopyranosyl-(1 → 6)-O-β-d-glucopyranosyl ester (5), named mutongsaponin A, B, C, D and E, respectively.

Bidesmoside triterpenoid glycosides from Stauntonia chinensis and relationship to anti-inflammation

Ten triterpenoid glycosides, yemuoside YM26-35 (1-9 and 12), were isolated from a traditional Chinese medicine known as "Ye Mu Gua" (Stauntonia chinensis DC.) along with two known ones, kalopanax saponin C (10) and sieboldianoside A (11). Their

Saponins from Leaves of Acanthopanax senticosus HARMS., Ciwujia; Structures of Ciwujianosides B, C1, C2, C3, C4, D1, D2 and E

Eleven triterpenoid saponins were isolated from the leaves of a Chinese folk medicine, Acanthopanax senticosus (RUPR. et MAXIM) HARMS.Of these compounds, three were identified as known saponins.The structures of eight new saponins named ciwujianosides B (1), C1, (2), C2 (3), C3 (4), C4 (5), D1 (6), D2 (7), and E (8) were elucidated to be as follows: (1), 3-O-α-rhamnopyranosyl-(1->2)-β-arabinopyranosyl-30-norolean-12,20(29)-dien-28-oic acid 28-O-α-rhamnopyranosyl-(1->4)-β-glucopyranosyl-(1->6)-β-glucopyranosyl ester; (2), 3-O-α-arabinopyranosyl-30-norolean-12,20(29)-dien-28-oic acid 28-O-α-rhamnopyranosyl-(1->4)-β-glucopyranosyl-(1->6)-β-glucopyranosyl ester; (3), 3-O-α-rhamnopyranosyl-(1->2)-α-arabinopyranosyl-30-norolean-12,20(29)-dien-28-oic acid 28-O-α-rhamnopyranosyl-(1->4)-6-O-acetyl-β-glucopyranosyl-(1->6)-β-glucopyranosyl ester; (4), 3-O-α-arabinopyranosyl oleanolic acid 28-O-α-rhamnopyranosyl-(1->4)-β-glucopyranosyl(1->6)-β-glucopyranosyl ester; (5), 3-O-α-rhamnopyranosyl-(1->2)-α-arabinopyranosyl oleanolic acid 28-O-α-rhamnopyranosyl-(1->4)-6-O-acetyl-β-glucopyranosyl-(1->6)-β-glucopyranosyl ester; (6), 3-O-α-arabinopyranosyl oleanolic acid 28-O-α-rhamnopyranosyl-(1->4)-6-O-acetyl-β-glucopyranosyl(1->6)-β-glucopyranosyl ester; (7), 3-O-α-arabinopyranosyl-30-norolean-12,20(29)-dien-28-oic acid 28-O-α-rhamnopyranosyl-(1->4)-6-O-acetyl-b-glucopyranosyl-30-norolean-12,20(29)-dien-28-oic acid 28-O-α-rhamnopyranosyl-(1->4)-6-O-acetyl-β-glucopyranosyl-(1->6)-β-glucopyranosyl ester; (8), 3-O-α-rhamnopyranosyl-(1->2)-α-arabinopyranosyl-30-norolean-12,20(29)-dien-28-oic acid.Keywords - Acanthopanax senticosus; Araliaceae; saponin; Chinese folk medicine; ciwujianoside; oleanolic acid glycoside; noroleanolic acid glycoside; 30-norolean-12,20(29)-dien-28-oic acid; ciwujia