104789-46-0Relevant articles and documents
6-purinyl N-/2-chloroethyl/carbamate and thiocarbamate and process for the preparation thereof
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, (2008/06/13)
6-purinyl N-(2-chloroethyl) carbamate and thiocarbamate are disclosed of the general formula I, STR1 in which X stands for an oxygen or sulfur atom, and also a process for their preparation by reacting a purine derivative of the general formula II (hypoxanthine or 6-mercaptopurine, respectively) with 2-chloroethylisocyanate. The subject compounds of formula I show a remarkable antineoplastic effect in vitro and in vivo, and consequently have great potential for the treatment of malignant neoplastic diseases in mammals.