104795-33-7Relevant academic research and scientific papers
Synthesis of Homochiral 4-Amino-4-carboxy-2-phosphonomethylpyrrolidines via a Diastereoselective Bucherer-Bergs Reaction of 4-Oxopyrrolidine Derivative: Novel Conformationally Restricted AP 5 Analogues
Tanaka, Ken-ichi,Iwabuchi, Hirokazu,Sawanishi, Hiroyuki
, p. 2271 - 2280 (1995)
Asymmetric synthesis of 4-amino-4-carboxy-2-phosphonomethylpyrrolidines 1 and 2, which can be viewed as novel conformationally restricted analogues of 2-amino-5-phosphonopentanoic acid (AP 5) incorporated into the pyrrolidine ring, was achieved from trans-4-hydroxy-L-proline as a homochiral starting material using the diastereoselective Bucherer-Bergs reaction of (2S)-1-benzyl-2--4-oxopyrrolidine 12.
