1047973-99-8

Basic information

• Product Name: (S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-nitrobutanal
• Synonyms: (S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-nitrobutanal
• CAS NO: 1047973-99-8
• Molecular Weight: 307.346
• Mol File: 1047973-99-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-nitrobutanal(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-nitrobutanal(1047973-99-8)
• EPA Substance Registry System: (S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-nitrobutanal(1047973-99-8)

Safety Data

• Hazardous Substances Data: 1047973-99-8(Hazardous Substances Data)

Upstream product

• 133332-34-0 (E)-3-(3-cyclopentyloxy-4-methoxyphenyl)acrylaldehyde 
• 75-52-5 nitromethane 
• 141332-74-3 2-(cyclopentyloxy)-1-methoxy-4-(2-nitrovinyl)benzene 
• 75-07-0 acetaldehyde 
• 621-59-0 isovanillin 
• 67387-76-2 3-cyclopentyloxy-4-methoxybenzylaldehyde 
• 138509-45-2 4-bromo-2-cyclopentyloxyanisole 
• 90-05-1 2-methoxy-phenol 
• 37942-01-1 5-bromo-2-methoxyphenol 

Downstream Products

• 85416-73-5 (S)-rolipram 

Relevant articles and documents

Enantioselective Flow Synthesis of Rolipram Enabled by a Telescoped Asymmetric Conjugate Addition-Oxidative Aldehyde Esterification Sequence Using in Situ-Generated Persulfuric Acid as Oxidant

A novel approach is reported for the enantioselective flow synthesis of rolipram comprising a telescoped asymmetric conjugate addition-oxidative aldehyde esterification sequence followed by trichlorosilane-mediated nitro group reduction and concomitant la

Biocatalytic Michael-type additions of acetaldehyde to nitroolefins with the proline-based enzyme 4-oxalocrotonate tautomerase yielding enantioenriched γ-nitroaldehydes

Call me Michaelase: The enzyme 4-oxalocrotonate tautomerase (4-OT) promiscuously catalyzes the Michael-type addition of acetaldehyde to a collection of aromatic and aliphatic nitroolefins with high stereoselectivity producing precursors of γ-aminobutyric

Chiral ionic liquids bearing O-silylated α,α-diphenyl (S)- Or (R)-prolinol units: Recoverable organocatalysts for asymmetric michael addition of nitroalkanes to α,β-enals

Chiral ionic liquids bearing O-silylated α,α-diphenyl (S)- or (R)-prolinol units tagged to the imidazolium cation were synthesized and their activity as catalysts in the Michael addition of nitroalkanes to α,β-unsaturated aldehydes was evaluated. Respective (S) or (R) adducts were obtained in the reactions in high yields (up to 95 %) and with high enantio-selectivity (up to 99% ee). Remarkably, the immobilized orgariocatalysts could be used five times without any decrease in product: yields or ee values. (R)-Michael adducts could be easily transformed into the most active (R) enantiomers of medications Phenibut, Baclofen, and Rolipram for the treatment of CNS disorders.