104798-89-2Relevant academic research and scientific papers
A concise microwave-assisted synthesis of 2-aminoimidazole marine sponge alkaloids of the isonaamines series
Ermolat'ev,Alifanov,Rybakov,Babaev,Van Der Eycken
experimental part, p. 2083 - 2088 (2009/04/03)
A short and efficient route to 1,4-substituted 2-aminoim-idazole alkaloids starting from the easily accessible 2-alkylami-nopyrimidines and α-bromo aldehydes is reported. The formation of the intermediate imidazo[l,2-a] pyrimidinium salts and subsequent cleavage were facilitated by microwave irradiation. Marine sponge alkaloids preclathridines A, C and isonaamines A, C, D were obtained in high yields using the optimized one-pot two-step procedure. Thieme Stuttgart.
