104807-46-7 Usage
Uses
Used in Pharmaceutical Industry:
Methoctramine tetrahydrochloride hemihydrate is used as a muscarinic receptor 2 antagonist for its ability to block the muscarinic M2 receptors, which play a crucial role in various physiological processes.
Used in Research Applications:
Methoctramine tetrahydrochloride hemihydrate is used as a test molecule to study its effect on premature osteogenic differentiation of Hutchinson-Gilford progeria syndrome (HGPS) iPS (induced pluripotent)-derived mesenchymal stem cells. This helps researchers understand the role of muscarinic M2 receptors in the development of this rare genetic disorder and potentially develop treatments.
Biochem/physiol Actions
Methoctramine is a selective M2 muscarinic receptor antagonist at nM concentrations. At mM concentrations, methoctramine directly inhibits the high affinity GTPase activity of G proteins. In oesophageal muscle, acetylcholine-mediated increase in calcium and arachidonic acid release were reduced by the M2 receptor antagonist, methoctramine. Methoctramine infused bilaterally in the dorsolateral striatum, considerably enhanced memory in cognitively impaired aged rats. Methoctramine plays a vital role in muscarinic receptor classification.
Check Digit Verification of cas no
The CAS Registry Mumber 104807-46-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,8,0 and 7 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 104807-46:
(8*1)+(7*0)+(6*4)+(5*8)+(4*0)+(3*7)+(2*4)+(1*6)=107
107 % 10 = 7
So 104807-46-7 is a valid CAS Registry Number.
InChI:InChI=1/C36H62N4O2.4ClH/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2;;;;/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3;4*1H
