104807-46-7

Basic information

• Product Name: methoctramine tetrahydrochloride hemihydrate
• Synonyms: methoctramine hemihydrate;methoctramine tetrahydrochloride hemihydrate;methoctramine;Methoctramine hemihydrate tetrahydrochloride, N,Nμ-bis[6-[[(2-Methoxyphenyl)methyl]amino]hexyl]-1,8-octane diamine hemihydrate tetrahydrochloride;MethoctraMine hydrate;Methoctramine tetrahydrochloride hydrate;N,N′-bis[6-[[(2-Methoxyphenyl)methyl]amino]hexyl]-1,8-octane diamine tetrahydrochloride hydrate
• CAS NO: 104807-46-7
• Molecular Formula: 2C36H62N4O2.4ClH.H2O
• Molecular Weight: 1329.68
• Mol File: 104807-46-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 681.9°Cat760mmHg
• Flash Point: 316.7°C
• Appearance: white/
• Density: g/cm³
• Vapor Pressure: 1.89E-18mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: H2O: >20mg/mL
• CAS DataBase Reference: methoctramine tetrahydrochloride hemihydrate(CAS DataBase Reference)
• NIST Chemistry Reference: methoctramine tetrahydrochloride hemihydrate(104807-46-7)
• EPA Substance Registry System: methoctramine tetrahydrochloride hemihydrate(104807-46-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 104807-46-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 104807-46-7 differently. You can refer to the following data:
1. Methoctramine is a muscarinic M2 receptor antagonist.
2. Methoctramine hydrate has been used: As a muscarinic receptor 2 antogonist. As a test molecule to check its effect on premature osteogenic differentiation of HGPS (Hutchinson-Gilford progeria syndrome) iPS (induced pluripotent)-derived mesenchymal stem cells.

Definition

ChEBI: A hydrochloride obtained by combining methoctramine with four molar equivalents of hydrochloric acid.

General Description

Methoctramine (N, N′-bis [6-[[(2-methoxyphenyl)-methyl] hexyl]-1, 8-octane] diamine) is a derivative of polymethylene tetramine.

Biochem/physiol Actions

Methoctramine is a selective M2 muscarinic receptor antagonist at nM concentrations. At mM concentrations, methoctramine directly inhibits the high affinity GTPase activity of G proteins. In oesophageal muscle, acetylcholine-mediated increase in calcium and arachidonic acid release were reduced by the M2 receptor antagonist, methoctramine. Methoctramine infused bilaterally in the dorsolateral striatum, considerably enhanced memory in cognitively impaired aged rats. Methoctramine plays a vital role in muscarinic receptor classification.

InChI:InChI=1/C36H62N4O2.4ClH/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2;;;;/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3;4*1H