104809-02-1

Basic information

• Product Name: METHYLMALONYL COENZYME A LITHIUM
• Synonyms: METHYLMALONYL COENZYME A LITHIUM;METHYLMALONYL COENZYME A TETRALITHIUM &;methylmalonyl coenzyme a tetralithium salt hydrate;α-methylmalonyl coenzyme a tetralithium salt;3-[2-[3-[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]aminopropanoylamino]ethylsulfanyl]-2-methyl-3-oxo-propanoic acid;Methylmalonyl-CoA;coenzyme A methylmalonyl derivative, tetralithium hydrate;coenzyme A methylmalonyl derivative, lithium salt
• CAS NO: 104809-02-1
• Molecular Formula: C25H36Li4N7O19P3S1
• Molecular Weight: 891.34
• Mol File: 104809-02-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.92g/cm³
• Refractive Index: 1.72
• Storage Temp.: −20°C
• Solubility: H2O: 50 mg/mL, clear, colorless
• CAS DataBase Reference: METHYLMALONYL COENZYME A LITHIUM(CAS DataBase Reference)
• NIST Chemistry Reference: METHYLMALONYL COENZYME A LITHIUM(104809-02-1)
• EPA Substance Registry System: METHYLMALONYL COENZYME A LITHIUM(104809-02-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-26-36
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 104809-02-1(Hazardous Substances Data)

Usage

Description

METHYLMALONYL COENZYME A LITHIUM is a chemical compound that plays a crucial role in various biochemical processes. It is involved in the metabolism of certain amino acids and fatty acids, and its levels can be used as a diagnostic tool for certain genetic and metabolic disorders.

Uses

Used in Biochemical Research:
METHYLMALONYL COENZYME A LITHIUM is used as a reagent in the preparation of calibration curves for ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS). This technique is employed to accurately measure and analyze the levels of various compounds, including METHYLMALONYL COENZYME A LITHIUM, in biological samples.
Used in Enzyme Activity Assays:
METHYLMALONYL COENZYME A LITHIUM is used as a substrate in the measurement of enzyme activities, specifically methylmalonyl-CoA mutase and methylmalonyl-CoA epimerase. These enzymes are involved in the metabolism of certain amino acids and fatty acids, and their activity levels can provide valuable information about an individual's metabolic health.
Used in Diagnostic Testing:
METHYLMALONYL COENZYME A LITHIUM levels can be used as a diagnostic tool for certain genetic and metabolic disorders, such as methylmalonic acidemia and vitamin B12 deficiency. By measuring the levels of METHYLMALONYL COENZYME A LITHIUM in a patient's blood or urine, healthcare professionals can identify and monitor these conditions, allowing for appropriate treatment and management.

Biochem/physiol Actions

Methylmalonyl coenzyme A (CoA) is a catabolite of odd-chain fatty acids, cholesterol and few amino acids like valine, isoleucine, methionine, threonine. It is produced by the activity of the enzyme propionyl-CoA carboxylase(PCC). Methylmalonyl coenzyme A (CoA) is converted to succinyl-CoA by the methylmalonyl-CoA mutase (MCM) and vitamin B12 as the cofactor. Either a low MCM activity or an altered metabolism of vitamin B12 causes the inherited metabolic disease methylmalonic acidemia (MMA).

InChI:InChI=1/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/t12-,13+,16+,17+,18?,22+/m0/s1