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7-Methylguanosine 5'-triphosphate sodium salt, also known as m7GTP, is a synthetic nucleotide that serves as a structural analog of the mRNA cap. It plays a crucial role in the study of eukaryotic cellular mRNA cap structures and mechanisms, particularly in the context of mRNA's involvement in protein synthesis. 7-METHYLGUANOSINE 5'-TRIPHOSPHATE SODIUM SALT is characterized by the presence of a methyl group at the 7-position of the guanosine base, which is essential for its function and interactions with other molecules.

104809-18-9

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104809-18-9 Usage

Uses

Used in Biochemical Research:
7-Methylguanosine 5'-triphosphate sodium salt is used as a research tool for studying the structures and mechanisms of eukaryotic cellular mRNA caps. It aids in understanding the role of mRNA caps in protein synthesis and their interactions with various cellular components.
Used in Affinity Media Development:
m7GTP is utilized in the creation of affinity media for the capture and purification of molecules such as the eukaryotic initiation factor eIF4E. This application is vital for the development of novel techniques and methods in molecular biology and biotechnology, enabling the isolation and characterization of specific proteins and other biomolecules involved in mRNA translation and regulation.
Used in Pharmaceutical Industry:
7-Methylguanosine 5'-triphosphate sodium salt may have potential applications in the pharmaceutical industry, particularly in the development of drugs targeting mRNA processing and translation. Its ability to mimic the mRNA cap structure could be leveraged to design molecules that modulate gene expression and protein synthesis, offering new therapeutic opportunities for various diseases and conditions.

Biochem/physiol Actions

7-Methylguanosine 5′-triphosphate (m7GTP) inhibits in vitro protein synthesis by binding to translation initiation complexes. m7GTP is useful to study the structures and mechanisms of eukaryotic cellular mRNA caps in the context of mRNA involvement in protein synthesis. m7GTP has a high affinity for eukaryotic initiation factor eIF4E and may be used to create affinity media for their capture and purification.

Check Digit Verification of cas no

The CAS Registry Mumber 104809-18-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,8,0 and 9 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 104809-18:
(8*1)+(7*0)+(6*4)+(5*8)+(4*0)+(3*9)+(2*1)+(1*8)=109
109 % 10 = 9
So 104809-18-9 is a valid CAS Registry Number.

104809-18-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name sodium,[[[(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxido-3,6-dihydropurin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate

1.2 Other means of identification

Product number -
Other names 7-Methylguanosine 5 inverted exclamation marka-triphosphate sodium salt

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:104809-18-9 SDS

104809-18-9Upstream product

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