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10481-25-1

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10481-25-1 Usage

General Description

Spiro[3.3]heptane-2,6-dicarboxylic acid monomethyl ester belongs to the class of organic chemicals known as spiro compounds. As part of the ester group of compounds, it is characterized by dual carbonyl and ester groups, which grant it particular chemical properties and reactivity. Its name indicates its cyclic, or 'spiro', configuration of seven carbon atoms (heptane) with two carboxyl groups at positions 2 and 6 on the carbon chain. The term 'monomethyl ester' signifies that one of these carboxyl groups has reacted with a methanol molecule to form an ester group, while the other remains a carboxyl group. spiro[3.3]heptane-2,6-dicarboxylic acid monomethyl ester does not have much information available about its specific uses, applications, or hazards, hence it could be primarily used in scientific research and experimentation.

Check Digit Verification of cas no

The CAS Registry Mumber 10481-25-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,4,8 and 1 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 10481-25:
(7*1)+(6*0)+(5*4)+(4*8)+(3*1)+(2*2)+(1*5)=71
71 % 10 = 1
So 10481-25-1 is a valid CAS Registry Number.

10481-25-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name Spiro[3.3]heptane-2,6-dicarboxylic acid monomethyl ester

1.2 Other means of identification

Product number -
Other names 2-methoxycarbonylspiro[3.3]heptane-6-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10481-25-1 SDS

10481-25-1Relevant articles and documents

(±)-N9-(2-(hydroxymethyl)spiro[3.3]hept-6-yl)adenine. The first biologically active saturated analogue of adenallene with axial dissymmetry

Jones,Drach,Corbett,Kessel,Zemlicka

, p. 6277 - 6280 (1995)

Synthesis of the title analogue 2 is described. Fecht's acid (3) was esterified with N,N-dimethylformamide dimethyl acetal to give monoester 4 along with diester 5. Compound 4 was transformed to ester amide 6 by the reaction with isobutyl chloroformate and triethylamine followed by ammonolysis. Hoffman rearrangement of 6 effected by lead tetraacetate in tert-butyl alcohol led to the N-tert-butoxycarbonyl ester 7. The latter was reduced with Ca(BH4)2 to give the protected amino alcohol 8. Removal of the N-tert-butoxycarbonyl group with 2 M HCl in methanol afforded the hydrochloride of amino alcohol 2. Reaction of 9 with 5-amino-4,6-dichloropyrimidine and triethylamine gave the pyrimidine derivative 10 which, in turn, was cyclized to 6-chloropurine 11a. Ammonolysis of the latter intermediate afforded the title analogue 2. The 1H NMR spectrnm of Fecht's acid (3) in CD3COCD3 showed that four methylene protons were magnetically nonequivalent (two quartets) whereas the other four were equivalent, forming a single doublet. Compound 2 inhibited the replication of human cytomegalovirus (IC50 32 μM) and growth of murine leukemia L1210 cells (IC50 30 μM). Zone assays showed inhibition of the following tumor cultures at 0.5 mg/disk: murine leukemia P388, mouse tumors PO3, C38, and M17/Adr as well as human tumors MCF-7 and CX-1.

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