104813-92-5

Basic information

• Product Name: 2-(1-Piperazinyl)-3-pyridinecarboxylic acid methyl ester
• Synonyms: 2-(1-Piperazinyl)-3-pyridinecarboxylic acid methyl ester;Methyl 2-(piperazin-1-yl)nicotinate;2-Piperazin-1-yl-nicotinic acid methyl ester
• CAS NO: 104813-92-5
• Molecular Formula: C11H15N3O2
• Molecular Weight: 221.26
• Product Categories: pharmacetical
• Mol File: 104813-92-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 379.3°Cat760mmHg
• Flash Point: 183.2°C
• Appearance: /
• Density: 1.171g/cm³
• Vapor Pressure: 5.93E-06mmHg at 25°C
• Refractive Index: 1.544
• CAS DataBase Reference: 2-(1-Piperazinyl)-3-pyridinecarboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-Piperazinyl)-3-pyridinecarboxylic acid methyl ester(104813-92-5)
• EPA Substance Registry System: 2-(1-Piperazinyl)-3-pyridinecarboxylic acid methyl ester(104813-92-5)

Safety Data

• Hazardous Substances Data: 104813-92-5(Hazardous Substances Data)

Usage

Chemical structure

A methyl ester derivative of 2-(1-piperazinyl)pyridine-3-carboxylic acid

Usage

Commonly used in medicinal chemistry

Potential effects

Has been studied for its potential as a central nervous system depressant, as a potential treatment for anxiety and depression, and for its potential anti-inflammatory and anti-cancer properties

Research

Versatile compound and has been the subject of extensive research in various fields of medicine and pharmacology.

InChI:InChI=1/C11H15N3O2/c1-16-11(15)9-3-2-4-13-10(9)14-7-5-12-6-8-14/h2-4,12H,5-8H2,1H3

Upstream product

• 110-85-0 piperazine 
• 40134-18-7 methyl 2-chloropyridine-3-carboxylate 
• 2942-59-8 2-chloronicotinic acid 

Relevant articles and documents

Atypical Antipsychotic Agents: Patterns of Activity in a Series of 3-Substituted 2-Pyridinyl-1-piperazine Derivatives

A series of 3-substituted 2-pyridinyl-1-piperazine derivaties have been appended to cyclic imide groups and evaluated for their potential antipsochotic activity.The dopamine receptor affinities of these target molecules, as well as their ability to block apomorphine-induced stereotypy or reverse neuroleptic-induced catalepsy, was dependent on the lipophilic and electronic characteristics of the substituent situated on the pyridine ring.Groups with +? and -? values were most consistent with the desired biological profile of the target molecules, the cyano moiety being the optimum choice.Evaluation of compound 12 in a monkey model of amphetamine psychosis, and the regional selectivity it expresses for the A10 dopaminergic cell bodies in electrophysiological experiments, suggest this compound would be an atypical antipsychotic agent with few side effects.