104827-27-2Relevant academic research and scientific papers
Kumada-Corriu reactions of alkyl halides with alkynyl nucleophiles
Yang, Lian-Ming,Huang, Li-Fu,Luh, Tien-Yau
, p. 1461 - 1463 (2004)
Pd2(dba)3-Ph3P-catalyzed Kumada-Corriu coupling reactions of unactivated alkyl bromides or iodides with an alkynyl nucleophile furnish Csp-Csp3 bond formation. Alkynyl nucleophiles can be alkynyllithiums or the corresponding Grignard reagents. The superior performance of Ph3P ligand over the trialkylphosphine ligands indicates that this cross-coupling reaction may be a reductive-elimination-controlled process.
Methode de synthese d'acides gras marques substitues ou non en α et en β
Apparu, Marcel,Comet, Michel,Leo, Pierre M.,Mathieu, Jean-Paul,Du Moulinet, Amaury,et al.
, p. 118 - 124 (2007/10/02)
2-Propyn-1-ol and the dibromides Br(CH2)nBr (n = 10-12) have been used as starting materials for the synthesis of α- and β-methyl-branched fatty acids (C16) labeled with 123I at the ω-position.The methyl groups are introduced through the use of the lithium salt of either propanoic or isobutyric acid.The synthesis of *IC6H5(CH2)14COOH and *IC6H5(CH2)12CH(CH3)CH2COOH have been achieved in the same way starting from phenylacetylene.In each case, the radioactive iodine atom is introduced by an I/*I exchange reaction.
